Our core generated several types of transgenic micea stable humanized ACE2 mice using a combi-CRISPR genetic engineering technique. We hope these mouse models can help to dissect COVID-19 pathogenic mechanismthe interaction(s) between spike proteinACE2 K353.

Our core generated the mouse model that can express human ACE2 in specific tissue. This model can be used to study the infection mechanismpathway. In addition, we also generate a humanized Ace2 H353K mice by genetic engineering. This model can be used to study the interaction(s) between spike proteinACE2 K353.

These mouse models can use tissue-specific cre to rapidly generating the mouse which present human ACE2 in specific tissue. Due to the rapid generationthe specificity, these mouse models are typically used for preclinical application in the development of vaccines, small molecule drugs,the research of SARS-CoV-2 infection mechanism.

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