Technical Name |
Therapeutic stem cell lines(CASCMT) for canine mitochondrial transplantation |
Project Operator |
Graduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science |
Project Host |
柯冠銘 |
Summary |
Through the computer-controlled suspension cell culture system, CASCMT can proliferate stably for up to 100 generations,the 100th generation of CASCMT can be used for mitochondrial transplantation to allow xenotransplantation (low rejection), while significantly reducing bacterial lipopolysaccharide-induced cell damage, showing that CASCMT The clinical treatment can greatly reduce the risk of infection, reduce the use of antibiotics,facilitate the clinical standardization to replace canine autologous stem cell transplantation. |
Scientific Breakthrough |
CASCMT 技術透過粒線體移植可應用於各種犬隻粒腺體老化或受損之相關疾病, 工業化培養之CASCMT可將粒線體移植有效劑量與治療時程標準化,取代犬隻自體幹細胞培養製程(細胞增殖數量不穩定與藥理路徑不明),有效增加臨床治療成功率。 |
Industrial Applicability |
CASCMT is a full suspension cultured cell that can be applied to a standard industrial cell mass production system. It can stably produce a large number of cell lines in a short period of time, provide clinical routine cell therapy, replace traditional canine autologous stem cell transplantation. CASCMT can be used in post-operative therapy for dogs by using transplanted healthy mitochondria to assist tissue cell regeneration,reduce surgical complicationswound healing time,antibiotic use. Clinically, it can be applied to the organ diseases with high mitochondrial manifestations. By ultrasound-guided injection system, CASCMT is suitable for low-invasive therapycan reduce the risk of complicationsstress in clinic. |
Keyword |
Mitochondrial transplantation Stem cell therapy Adipose stem cells Canine arthritis Joint degeneration Allogeneic stem cell transplantation Autologous stem cell transplantation Mitochondrial disease Stem cell mass production Veterinary |