Derinat potentiates an efficient approach to deal with the hair follicle diseases and protect hair follicles and skin tissue from endogenous oxidative stress.

Derinat, a DNA sodium salt composition with 270–500 KDa is isolated from the soft roes of Acipenser gueldenstaedtii. Our study found Derinat protected skin cells (primary keratinocytes and human dermal fibroblast) from endogenous oxidative stress. Derinat efficiently alternated Ca2+ mobility form the transient receptor potential canonical channels, blocked intracellular reactive oxygen species (ROS) production from Ca2+-overloaded mitochondria. Besides, treatment by Derinat in BALB/c-nu mice significantly restrained ROS production in mice skin, and simultaneously promoted hair follicles growth through activating hair follicle stem cells with the markers of CD49f and Oct3/4. Conclusively, Derinat has no toxicity in treating skin and decreases intracellular ROS formation form activated Ca2+ signaling; furthermore, hair follicles are increased in nude mice and extend the anagen stage by treating Derinat. This study provides Derinat potentiates an efficient approach to deal with the hair follicle diseases and protect hair follicles and skin tissue from endogenous oxidative stress.

sodium DNA天然組合物可運用在毛囊疾病或保健上面，提供一個最大的療效與預防。