This project designs a biomedical theranostic chip for neural disorders. It can not only function as an implantable device for treating the Parkinson＇s disease, depression, dementia, but also monitor physiological signals in wearable devices. For the development of medical device, the NeuLive system based on the microchip can accelerate the pre-clinical data collectionverification.

We developed a new type of microfluidic chip with utilizing the characteristic of sperm anadromous instinct for high-throughput sperm separation. The process can be finished in 10 min, which is 10 times faster than the conventional design. Experiment reveals that the qualified sperm motility was raised up from 30 to 99linearity (LIN) up from 0.2 to 0.85 via sorting by our microfluidic chip.

This product provides "Microfluidic sensing system for on-site rapid detection of early-stage acute kidney injury" for the hospital＇s intensive care unit, operating room, nephrology departmentcardiology department. It can replace the lengthycumbersome traditional instrumentationeasily access at the point of care.

We constructed a model to differentiate different neurodegenerative diseases by using blood-based biomarkers. Linear Discriminant Analysis (LDA) was used to reduce dimensionsMICE (Multivariate Imputation by Chained Equations) was used for missing value treatmentchoose CART model to predict missing value imputation. This machine learning model would be used for early dectection of neurodegenerative diseases.

A stem cell continuous harvest method was proposed. In this method, stem cells are partially detached. The remaining cells are continuously cultured by expansion in fresh culture medium.

A flexible PPG sensor patch for measuring pulsations of blood vessels estimating ambulatory blood pressure monitoring (ABPM). The measured quality PPG signals are analyzed to estimate blood pressure (BP), heart rate (HR), blood oxygen (SpO2)atrial fibrillation (A-Fib)avoid motion artifacts. In this way, with subject’s physiological condition apprehended accurately.

Our team has developed technology to build lung-on-a-chip with the aim of creating alternatives for animal researchachieving more accuratereliable preclinical experimental data.The chip＇s rapideffective screening ability will help the clinical community to reduce costsdrastically shorten the drug-development process.

This project proposes a smart contact lens ideally capable of simultaneously observing the tear evaporation rate, the tear osmolarity,the ocular surface temperature. To solve the shortcoming of the current difficulty in quantifying DES, assist doctors in the diagnosis of dry eye conditions, the effectivenessselectivity of drugs, the treatment statusrecovery level.

The microfluidic chips have been used to sort human motile sperms based on the phenomena of laminar flow. The sorted sperms would be fertilized to form the embryo by using in intracytoplasmic sperm injection (ICSI). The prototype of chips have been developed in the lab under National Tsing Hua University. Furthermore, the mass production has been conducted by Ritek to accomplish the disposable chips

The chromium-doped zinc gallate, ZnGa2O4:Cr3+, material is viewed as a long-lasting luminescent phosphor which can avoid tissue autofluorescence interference for in vivo imaging detection. The cubic ZGC revealed a specific accumulation in liver0.5 Gy used at the end of X-ray excitation was sufficient for imaging of deep seated hepatic tumors.

This rapid diagnostic device for monitoring the abnormal growth of the endometrial tissue is expected to allow women to detect whether VEGFIL-6 are too high at home in a simplerapid manner. These two factors are also increasing in some gynecological cancers. Through the new device, it is convenient for women to self-monitoring women physiologically-relevant diseasespossible causes of abnormal bleeding in the future,seek appropriate medical treatment early.

We have displayed AChE on insect cell membrane for the detection of OPCB pesticide residue. Compared to GC-MSLC-MS analysis, the cost of our system is much lower with time-saving comparing with conventional biochemical detection method, the enzyme extractionpurification from flies is not necessary in our system. Therefore, this is a fast, accurateeconomical choice for residue screening.

Our IoT of food allergen detection system has high sensitivityspecificity by magnetic nano-beads with advanced material coating. This advanced material successful inhibit biofouling in biosensor system. Other than this, Our system combine nanotechnology, biotechnology, IoTAI model. Device is small any easily carry to anywhere.

Due to the inconvenience of the conventional drip frame, this invention applies fuzzy control logican inverted-pendulum system to build up a reliable system, which facilitates patient mobilityensure safety with compensating the inclination angle of the piggyback intravenous drip frame based on the motion information of the patient.

The present sperm sorting chip utilities the upstream swim characteristic of sperms in appropriate fluid velocity to achieve up to 80 high motility sperm yield for infertile males in just 40 minutes

A 3D wireless tracking system for minimally invasive spine surgery navigation is developed based on the mm-wave radar technique. It has the benefit of multi-target trackingsmall-sized transponder. With the cooperation of radar systemtriangulation algorithm, the maximum error of 3D positioning is less than 1.8 mm in the distance of 1.2 m

We apply diffuse reflectance spectroscopy method to accurately determine the skin properties of subjects. Our device has a very simple configurationthe detected reflectance is processed with an advanced, efficient machine learning algorithm to quantify the skin composition of subjects.

The developed multi-functional bio-sensor chip has the advantages of excellent detection performance, wide application,low mass production. At present, we have already cooperated with upstreamdownstream manufacturers for mass production of the multifunctional bio-sensor chips. At the same time, cooperate with the instrument manufacturer to develop a simple portable electrochemical detect

During arthroscopic surgery, the anchor suture is easy to tangleunable to fix the soft tissue using conventional one lumen cannula. Thus we design a novel “Double lumen cannula” containing a flexible septum inside the cannula which can separatechange the cannula volume dynamically into two lumen. This would decrease the surgical timesoft tissue injury,improve the security of su