This project aims to incorporate the state-of-the-art InformationCommunication Technologies (ICT), the Internet of Things (IoT), Big Data techniques in linking every aspect of community-based integrated long-term care (LTC), improving the efficiency of care servicesadministrative process,to realize the idea of Aging in Place emphasized in the Long-term Care Policy 2.0 in Taiwan.

This system uses the innovative AIoT application to target annoying scalp maintenance problemsdevelops an intelligent scalp detectionmanagement system. The core of the technology is to use deep learning-based object detection models. Tens of thousands of microscopic image data sets that are labeledtrained for scalp symptoms. As a result, the scalp image recognition module is develop, such as dandruff, hair loss, oil, and inflammation, etc. Hence this system can provide scalp detection, and maintenance effectiveness tracking functions lead scalp maintenance services to a new level of intelligent management.

We developed a wearable ultrasound monitoring device to monitor the collapse of tongue roots of sleep respiratory patients throughout the night,completed clinical trials in the sleep center. The experimental results show that this device can effectively monitor OSA. The tongue structure changes at the timeintegrates ultrasound information into the commercial PSG system. It is expected

Our previous studies suggested that increase Cisd2 levels may attenuate the pathogenesis of NAFLD/NASH. Accordingly, potent Cisd2 activators with the capacity to enhance Cisd2 levels were identified through the screening of skeletally diverse collections and structural optimization. So far BPRCD0001S0 is the most potent Cisd2 activator obtained, which has been studied extensively. Data obtained revealed that BPRCD0001S0 has no detectable toxicity in vivo, can activate Cisd2 in liver and ameliorate obese-related and fructose-induced NAFLD/NASH.

Harmoscope is a virtual biopsy technology for dermatology. The superior performances of in vivo Harmoscope has been clinically validated by NTU hospital for 14 years, with the deepest penetration, super-resolution,the highest contrast all at the same time. Without imaging processinglabeling, Harmoscope raw images provide the same level of resolutioninformation as the time-consuming gold standard H&E histopathology, allowing dermatologists and pathologists to grade and classify various skin lesions for immediate therapeutic decision without physical biopsy. This award-winning technology will release the saturated loading of skin biopsy examination, greatly improve the quality of point of care, while providing a trauma-free real-time alternative for skin lesion patients.

This product is a novel risk assessment tool for carotid artery stenosis and stroke. This is a revolutionary healthcare technology using motion analysis and quantification to extract information from pulses for risk assessments. The entire process is completed by taking a short video clip aimed at the neck with only one simple click on any mobile devices or our apparatus, anywhere, anytime. In less than five minutes, the user receives an evaluation report indicating low to high stroke risk. Our product accuracy stands higher than 90% when compared to the clinical outcome. The future indications of this product can be extended to arrhythmia, venous fistula obstruction, etc. This product has the great potential to achieve our dream of “personalized mobile hospital” in the future world.

As we continue to face the rapid increase in confirmed Coronavirus cases around the world, we created an AI-based pneumonia detection platform for COVID-19. The system is able to automatically detect high-risk patients with pneumonia that will then send information to doctors. With that information, the doctors are then able to make follow-up decisions and provide a treatment plan after the diagnosis. In specific, doctors from the Department of Medical Imaging provided us thousands of positive and negative chest x-rays for pneumonia as a training set. Our system has already been tested with and adopted by doctors at the NCKU Hospital. The system achieved 95% accuracy to detect the pneumonia symptom, based on 1400 test images.

Our present invention firstly provides a new ultrasound (US)-multifunctional microbubble (MB) which can be applied to a topical region of the body surface of organisms by applyingsputtering, instead of using injection. Some interesting topics have been explored: 1. US-aided MBs facilitate the delivery of drugs to the inner ear via the transcanal method, 2. drug-carrying modified MB combine wit

A novel “Platform Technology” in surgical hemostasis, based on biodegradable polyurethane particles with anti-inflammatory and nerve repair, not only accelerates wound healing but also provides solutions for hemostasis during surgery, and improve biocompatibility and adverse of commercially hemostats to achieve the best patient care. Our first product is aimed to provide a hemostatic agent, use on the bleeding surface and deep, with additional functions to surgeons, which allows customers to shorten the operation time, reduce stay in the hospital, and reduce the chance of secondary surgery.

"PressureDOT team will develop the first intra-abdominal pressure monitoringlocalization micro internet device of things, to integrate into critical care vital sign monitoring systemtake care of the critical patients. This will ensure our role in the marketset up market barrier in this type of medical devices. With this platform, we can collect the continuous physical signal from c

Integrated Taiwan＇s superior industries such as semiconductor manufacturing processes, precision micro-molding, hot embossing,chip packaging to develop Pt/Au nano-alloy electrodes with applications in neutral non-enzymatic glucose biosensorsneutral non-enzymatic glucose biofuel cell. This novel Pt/Au nano-alloy electrode possesses advantages of technology foresight, good detection perfor

The "Herbmedotcin" technology platform is a major breakthrough in the several thousand years history of herbal medicine knowledge. Use patented technology to find potential natural functional molecules, with appropriate additivesoptimal processing conditions, to achieve a significant increase in their efficacy. This technology is also known as "molecular herbology". They h

Chronic wound infection is a leading cause of mortality in injured patients worldwide. At present, available systemic antibiotic treatments have an insufficient tissue penetration ability and allow the development of antibiotic-resistant pathogens. The identification of therapeutic agents with wound healing and antimicrobial functions is necessary to heal the wound and cure infections. Our report shows that the antimicrobial peptide (AMP) Epinecidin-1 (Epi-1) efficiently heals MRSA-infected heat burn injuries and provides protection from infection in mouse and pig model. Our results demonstrate that the biomaterial Epi-1 heals wounds through increasing epithelial cell proliferation, vascularization, and the formation of collagen and controls MRSA infection-mediated sepsis in pigs.

The high-frequency jet ventilator uses the solenoid valve and feedback techniques to control the operational parameters of the ventilator. The proposed dual-mode control mechanism allows dynamic adjustment of the tidal volume, pressure, and duration of ventilation simultaneously. The system has been verified in animal experiments and demonstrated a significant improvement in the gas exchange efficiency. Besides, the bioelectrical impedance measurement can provide real-time and accurate regional information of the lungs, which helps to monitor the patient’s condition during respiratory treatment. This work also adopts wireless communication and remote-control technology to reduce the risk of infection of medical professionals.

Here we present a portable microfluidic device that can perform immunoassay for infectious disease diagnosis or detect heavy metal ions in water samples. The device is composed of two major components: nanomaterials modified paper-based detection platform and semi-automated flow manipulator. A reusable 3D-printed device is used to hold a disposable detection pad that modified with functional nanomaterials for water quality monitoring or antibodies for disease diagnosis. Besides, the use of spring-containing 3D-printed syringes manipulates a large-volume sample without manual actuation. Meanwhile, by controlling the flow rate via the linked flow regulator at the syringe outlet, solutions can react stably with the paper platform, which provides detection and pre-concentration effects.

The bioactive corecorona synergism of sub-nanometer gold enables slowed inflammationincreased tissue regeneration in wound hypoxia. The developed dual-function wound dressing based on a gold nanocluster with a plane structurean adhesive layer presented two features: (1) the gold nanocluster can attenuate the inflammatory response by adjusting the strength of the active site (i.e., l

The interpretation of next generation sequencing is a big challenge. In order to improve the molecular diagnosis of the patient, we developed the AI_Variant prioritizer, a machine learning based variant prioterization system that can help to prioritize candidate variants for human disease. This module highlighted the possible disease causing variants to help clinician to increase the disease diagnostic yield and decrease the load of manpower.

Optical coherence tomography using an optical probe with a diameter of 0.9 mm, combined with the 14-18 gauge needle, is used for clinical needle puncture. Using the real-time image obtained from the tip of the needle in the tissue, the needle position can be identified. Combined with artificial intelligence can achieve objective, accurate and automatic identification of the tissue, which has been successfully verified in anesthesia and laparoscopic surgery.

This project will establish a National biobank consortium of Taiwan through the fund support from the government. The National Health Research Institutes will establish a Central Office for the collaboration works, which includes collecting the number of samples of the human biological database in each biobank that agreed to join the Consortium. All Alliance need to follow the same SOP for the collection processthe quality of the biosample. Adequateconsistent clinical data will also be established under the Information Security Management Treaty. Since the contents of the biobanks from different institute are quite different, we will be able to quickly establish a largecomprehensive biobank network.In line with the need of biotechnologypharmaceutical industries.

We developed a biomimetic triple-antibody-immobilized magnetic fucoidan nanomedicine as a multifunctional artificial antigen presenting cell, which possessed the ability to not only inhibit immune checkpoint but activate tumor infiltrated T cells. of Bridging sites with tunable density on the nanoplatform was designed, allowing the antibodies to be well-distributed on the surface for mimicking immune cells. In contrast to the complex cell expansion process using microbeads in adaptive cell therapy, the nanoplatform can be i.v. administrated to cut the course of therapy from several weeks to days. With the development of the platform technology, an artificial immune system family can be built to pave the way for personalized immunotherapy.

Diabetes is now still an incurable disease. Beta cell failure is one of common causes. No drugs for this failure have been developed. This invention is to developapply PS1 to treatreverse diabetes. PS1 is a first-in-class small-molecule drug, which targets beta cells by improving their survivalfunction. As a result, PS1 can treatreverse diabetes. The anti-diabetic mechanism of

EPICAn is a novel technique that uses liquid biopsy for epigenetic analysis. Using methylation-specific PCR method to analyze specific gene methylation of cell-free DNA in plasma for early detection of breast cancer. The advantages of this technology are 1. High accuracy 2. Low false positive rate 3. Low-invasive 4. less limitation 5. Available for routine continuous detection 6. Monitoring cancer changes 7. Aided diagnosis 8. Automated process 9. Easy-to-operate 10. Rapid analysis. It is expected that EPICAn technique can increase the accuracy of early detection of breast canceraid clinicians diagnosis.

X-ray diffraction technology is used to analyze the drug efflux pump, ST50, form S. Typhi. The drug efflux mechanism for multiple drug resistant (MDR) S. Typhithe potential location for antigen of market-based typhoid detection reagent are understood through this ST50 structure. It could help develop the more effective typhoid detection reagentthe new antibiotics against MDR S. Typhi.

This technique used algae-a natural raw ingredient as novel functional aquafeed additives, as replacement for fish meal in nutrition sources, a fish oil replacement in the feed, an algae strain contains unsaturated fatty acid can change level of serotoninblood cortisol in fish brain, decrease their cannibalism rate. This technique can reduce feed production costincrease harvesting rate.

We first reported that Bidens pilosa (BP), an ediblemedicinal plant, suppress coccidiosisgut bacterial infection as evidenced by increased survival rate, better performance, gut pathologymicrobiota in chickens. In addition, combining with probiotics with anti-pathogenic bacteria activityorganic acids synthesis are used as novel natural growth promoters to replace antibiotic growth promoters.

To develop a potential preservative from microorganisms, Aureobasidium pullulans was the positive candidates. In a laboratory scale, we introduced the Aureobasidium pullulans broth into a practical delivery chain to simulate the commercial process. For disease severitybanana degreening, the results indicated we could obtain a better consistencylonger storage time for exports as well.

Based on the optical fluorescence of the plant, the technology distinguishes the difference of the main protein infected by virus from the normal ones with the feature light. The main difference of this technology is to omit the complicatedbiochemical-material- consumption procedures. With the establishment of big data, the artificial intelligence algorithm identifies whether the implant is.

Our studies showed the endophyte Burkholderia 869T2 help banana to stand against the Panama diseaseimprove growths of pumpkin, cabbage,other crops. The 869T2 helps plants cope with salinity stresscan decrease dioxin accumulations in plants. The specific metabolite PQQ of 869T2 benefits host plant growths. The beneficial endophytethe metabolite can be developed as an protective endophytic agent.

Here, we introduce an electricity-free centrifuge platform based on a manual centrifuge. The provided centrifugal force is sufficient to produce a plasma purity of 99 separated in as little as 2−3 min. We then performed an immunoassay on a paper devicethe results were observed by a portable reader. As a result, the detection limit of the C-Reactive Protein is 1 ng/mL, with a total turnaround time of 7 min.