This technique used algae-a natural raw ingredient as novel functional aquafeed additives, as replacement for fish meal in nutrition sources, a fish oil replacement in the feed, an algae strain contains unsaturated fatty acid can change level of serotoninblood cortisol in fish brain, decrease their cannibalism rate. This technique can reduce feed production costincrease harvesting rate.

EPICAn is a novel technique that uses liquid biopsy for epigenetic analysis. Using methylation-specific PCR method to analyze specific gene methylation of cell-free DNA in plasma for early detection of breast cancer. The advantages of this technology are 1. High accuracy 2. Low false positive rate 3. Low-invasive 4. less limitation 5. Available for routine continuous detection 6. Monitoring cancer changes 7. Aided diagnosis 8. Automated process 9. Easy-to-operate 10. Rapid analysis. It is expected that EPICAn technique can increase the accuracy of early detection of breast canceraid clinicians diagnosis.

This system uses the innovative AIoT application to target annoying scalp maintenance problemsdevelops an intelligent scalp detectionmanagement system. The core of the technology is to use deep learning-based object detection models. Tens of thousands of microscopic image data sets that are labeledtrained for scalp symptoms. As a result, the scalp image recognition module is develop, such as dandruff, hair loss, oil, and inflammation, etc. Hence this system can provide scalp detection, and maintenance effectiveness tracking functions lead scalp maintenance services to a new level of intelligent management.

This project aims to incorporate the state-of-the-art InformationCommunication Technologies (ICT), the Internet of Things (IoT), Big Data techniques in linking every aspect of community-based integrated long-term care (LTC), improving the efficiency of care servicesadministrative process,to realize the idea of Aging in Place emphasized in the Long-term Care Policy 2.0 in Taiwan.

In this technology, a series of potent MOR/NOP agonists has been developed, which demonstrated potent antinociception in tail flick and cancer pain mouse models with fewer side-effects in respiratory suppression, heart rate decreasing, and constipation models than morphine.

BPRSJ338 exhibits high potency of anti-SARS-CoV-2 activity and is in development for fighting COVID-19 as a first-in-class drug. BPRSJ338 also potently inhibits against broad-spectrum coronaviruses including SARS-CoV-2, SARS-CoV, HCoV-229E, HCoV-OC43, TGEV, FIPV and MHV. Related US and Taiwan patents have been granted.​ Therefore it is also applicable to fight against severe evolving coronaviruses in the future.

DBPR807 can significantly suppress tumor growth, prevent distant metastasis, reduce angiogenesis, normalize tumor microenvironment and promote cytotoxic T-cell infiltration. In various HCC models, DBPR807 itself can prolong overall survival as effectively as marketed anti-angiogenic agent sorafenib and immune checkpoint inhibitor anti-PD-1 Ab. What’s more, its combination therapy with either sorafenib or anti-PD-1 Ab can extend life expectancy even more significantly than aforementioned monotherapy.

This technology is a development drug lead aiming to meet the medical needs of patients with small cell lung cancer. Through disturbing MYC-Aurora A interaction and inducing degradation of MYC oncoprotein, this bioavailable kinase inhibitor could serve as a potential treatment entity for SCLC.

We used the concepts of tissue regeneration, embedding drugs in biomaterial carriers,a rigorous regeneration deficient animal model with severe hind limb ischemia to develop an effective novel therapy Grace-001. The new drug can promote neovascularization, tissue regeneration, blood flow maintenance,restoration of blood vessels, nerves,muscles as well as their functions. This new dr

Diabetes is now still an incurable disease. Beta cell failure is one of common causes. No drugs for this failure have been developed. This invention is to developapply PS1 to treatreverse diabetes. PS1 is a first-in-class small-molecule drug, which targets beta cells by improving their survivalfunction. As a result, PS1 can treatreverse diabetes. The anti-diabetic mechanism of

We developed a biomimetic triple-antibody-immobilized magnetic fucoidan nanomedicine as a multifunctional artificial antigen presenting cell, which possessed the ability to not only inhibit immune checkpoint but activate tumor infiltrated T cells. of Bridging sites with tunable density on the nanoplatform was designed, allowing the antibodies to be well-distributed on the surface for mimicking immune cells. In contrast to the complex cell expansion process using microbeads in adaptive cell therapy, the nanoplatform can be i.v. administrated to cut the course of therapy from several weeks to days. With the development of the platform technology, an artificial immune system family can be built to pave the way for personalized immunotherapy.

Optical coherence tomography using an optical probe with a diameter of 0.9 mm, combined with the 14-18 gauge needle, is used for clinical needle puncture. Using the real-time image obtained from the tip of the needle in the tissue, the needle position can be identified. Combined with artificial intelligence can achieve objective, accurate and automatic identification of the tissue, which has been successfully verified in anesthesia and laparoscopic surgery.

Provided is an influenza mucosal vaccine compositionpreparationapplication thereof. This composition contains an antigen fusion protein which includes an influenza virus antigena Type IIb heat-labile enterotoxin A subunit. Immunization with the antigen fusion protein induces cellularhumoral immune responses, including systemicmucosal immune responses, against a specific in

The present invention discloses the germplasm bank of medicinal coral producing new targeted anti-cancer agent and their aquaculture technology platform. The medicinal corals are collected in Kenting, located at the southern tip of Taiwan. In response to the unmet medical needs of new anti-cancer drugs, our research results will provide more diverse types of new drug targets and lead compounds in the "new drug development-new drug discovery and exploration period".

The bioactive corecorona synergism of sub-nanometer gold enables slowed inflammationincreased tissue regeneration in wound hypoxia. The developed dual-function wound dressing based on a gold nanocluster with a plane structurean adhesive layer presented two features: (1) the gold nanocluster can attenuate the inflammatory response by adjusting the strength of the active site (i.e., l

The interpretation of next generation sequencing is a big challenge. In order to improve the molecular diagnosis of the patient, we developed the AI_Variant prioritizer, a machine learning based variant prioterization system that can help to prioritize candidate variants for human disease. This module highlighted the possible disease causing variants to help clinician to increase the disease diagnostic yield and decrease the load of manpower.

Here we present a portable microfluidic device that can perform immunoassay for infectious disease diagnosis or detect heavy metal ions in water samples. The device is composed of two major components: nanomaterials modified paper-based detection platform and semi-automated flow manipulator. A reusable 3D-printed device is used to hold a disposable detection pad that modified with functional nanomaterials for water quality monitoring or antibodies for disease diagnosis. Besides, the use of spring-containing 3D-printed syringes manipulates a large-volume sample without manual actuation. Meanwhile, by controlling the flow rate via the linked flow regulator at the syringe outlet, solutions can react stably with the paper platform, which provides detection and pre-concentration effects.

The high-frequency jet ventilator uses the solenoid valve and feedback techniques to control the operational parameters of the ventilator. The proposed dual-mode control mechanism allows dynamic adjustment of the tidal volume, pressure, and duration of ventilation simultaneously. The system has been verified in animal experiments and demonstrated a significant improvement in the gas exchange efficiency. Besides, the bioelectrical impedance measurement can provide real-time and accurate regional information of the lungs, which helps to monitor the patient’s condition during respiratory treatment. This work also adopts wireless communication and remote-control technology to reduce the risk of infection of medical professionals.

Chronic wound infection is a leading cause of mortality in injured patients worldwide. At present, available systemic antibiotic treatments have an insufficient tissue penetration ability and allow the development of antibiotic-resistant pathogens. The identification of therapeutic agents with wound healing and antimicrobial functions is necessary to heal the wound and cure infections. Our report shows that the antimicrobial peptide (AMP) Epinecidin-1 (Epi-1) efficiently heals MRSA-infected heat burn injuries and provides protection from infection in mouse and pig model. Our results demonstrate that the biomaterial Epi-1 heals wounds through increasing epithelial cell proliferation, vascularization, and the formation of collagen and controls MRSA infection-mediated sepsis in pigs.

A highly sensitivelinear ultrasonic radar was realized using digital self-injection-locking (SIL) technique. It can remotely monitor the vital signs of a human in motion, which will be demonstrated in this expo by upgrading a low-cost ultrasonic radar for reverse parking to support high-value telemedical applications. In the future it will further combine phased-array technology to implement non-contact 4D ultrasound system, which will bring disruptive innovation to medical technologies.

Integrated Taiwan＇s superior industries such as semiconductor manufacturing processes, precision micro-molding, hot embossing,chip packaging to develop Pt/Au nano-alloy electrodes with applications in neutral non-enzymatic glucose biosensorsneutral non-enzymatic glucose biofuel cell. This novel Pt/Au nano-alloy electrode possesses advantages of technology foresight, good detection perfor

A novel “Platform Technology” in surgical hemostasis, based on biodegradable polyurethane particles with anti-inflammatory and nerve repair, not only accelerates wound healing but also provides solutions for hemostasis during surgery, and improve biocompatibility and adverse of commercially hemostats to achieve the best patient care. Our first product is aimed to provide a hemostatic agent, use on the bleeding surface and deep, with additional functions to surgeons, which allows customers to shorten the operation time, reduce stay in the hospital, and reduce the chance of secondary surgery.

As we continue to face the rapid increase in confirmed Coronavirus cases around the world, we created an AI-based pneumonia detection platform for COVID-19. The system is able to automatically detect high-risk patients with pneumonia that will then send information to doctors. With that information, the doctors are then able to make follow-up decisions and provide a treatment plan after the diagnosis. In specific, doctors from the Department of Medical Imaging provided us thousands of positive and negative chest x-rays for pneumonia as a training set. Our system has already been tested with and adopted by doctors at the NCKU Hospital. The system achieved 95% accuracy to detect the pneumonia symptom, based on 1400 test images.

The innovative technology which is based on the unique biomimetic material, including immunomagnetic nanoparticles, aqueous extraction solvent,a portable IoT detection device promotes the detection speed, accuracy,precision of the target molecule. Featuring with the excellent ability of non-specific binding, this technology decreased the probability of false-negative/false-positive succe

This product is a novel risk assessment tool for carotid artery stenosis and stroke. This is a revolutionary healthcare technology using motion analysis and quantification to extract information from pulses for risk assessments. The entire process is completed by taking a short video clip aimed at the neck with only one simple click on any mobile devices or our apparatus, anywhere, anytime. In less than five minutes, the user receives an evaluation report indicating low to high stroke risk. Our product accuracy stands higher than 90% when compared to the clinical outcome. The future indications of this product can be extended to arrhythmia, venous fistula obstruction, etc. This product has the great potential to achieve our dream of “personalized mobile hospital” in the future world.

With the rapid growth of the aging population, the safety of the hospitalized elderly has become an important issue. Therefore, our team propose an innovative bed-exit alarm system using multiple sensors for bed-exit detection. With data fusion, IoTAI technologies, the system can achieve early detectionsignificantly reduce false alarms. In addition, it can realize real-time video streami

Our previous studies suggested that increase Cisd2 levels may attenuate the pathogenesis of NAFLD/NASH. Accordingly, potent Cisd2 activators with the capacity to enhance Cisd2 levels were identified through the screening of skeletally diverse collections and structural optimization. So far BPRCD0001S0 is the most potent Cisd2 activator obtained, which has been studied extensively. Data obtained revealed that BPRCD0001S0 has no detectable toxicity in vivo, can activate Cisd2 in liver and ameliorate obese-related and fructose-induced NAFLD/NASH.

We developed a wearable ultrasound monitoring device to monitor the collapse of tongue roots of sleep respiratory patients throughout the night,completed clinical trials in the sleep center. The experimental results show that this device can effectively monitor OSA. The tongue structure changes at the timeintegrates ultrasound information into the commercial PSG system. It is expected

A wearable sweat sensing device is developed for health monitoring during exercises to prevent illness caused by fluid losses. By biomimetic designchoosing material with high permeability, the sweat collector possesses high sweat collection efficiency, rapid transportlow response time. Inside the channel, salt concentrationsweat rate is deduced by electric property analysis. Finally

Harmoscope is a virtual biopsy technology for dermatology. The superior performances of in vivo Harmoscope has been clinically validated by NTU hospital for 14 years, with the deepest penetration, super-resolution,the highest contrast all at the same time. Without imaging processinglabeling, Harmoscope raw images provide the same level of resolutioninformation as the time-consuming gold standard H&E histopathology, allowing dermatologists and pathologists to grade and classify various skin lesions for immediate therapeutic decision without physical biopsy. This award-winning technology will release the saturated loading of skin biopsy examination, greatly improve the quality of point of care, while providing a trauma-free real-time alternative for skin lesion patients.