Two COVID-19 animal models, including humanized Ace2 micehuman peripheral blood lymphocyte transplanted mice, are used to mimic COVID-19 infection, immune responsecytokine release syndrome in human. The immune analytical platform can further outline the immune cell, cytokinebiomarker response pattern after viral infection. The COVID-19 humanized animal modelthe immune analytical platform will support COVID-19 related researchfacilitate new drugnew therapy validation.

Our PEDD has been used to detect the HNE level in both tearwound fluids of 9 patients,the limitations of detection were about 0.76 μg/mL0.63 μg/mL respectively. Our device requires only 15 minutes, 3 μL of clinical sample for each test,offers superior sensitivity compared to other current HNE detection methods. The HNE concentrations in the patient samples have shown that the elevated HNE levels might suggest an abnormal healing of either acutechronic wounds, consistent with previous studies that showed excess protease levels in all non-healing wounds.