Two COVID-19 animal models, including humanized Ace2 micehuman peripheral blood lymphocyte transplanted mice, are used to mimic COVID-19 infection, immune responsecytokine release syndrome in human. The immune analytical platform can further outline the immune cell, cytokinebiomarker response pattern after viral infection. The COVID-19 humanized animal modelthe immune analytical platform will support COVID-19 related researchfacilitate new drugnew therapy validation.

This technology is used to reveal the immune profiling of the tumor microenvironment based on multi-color immunohistochemistry staining. Each immune cell type will be probed with different fluorophores,the density, as well as the location of each immune cell type on the tissue slides, will be disclosed using inForm software.

"The IHC staining intensity grading algorithm combines a series of complementary processes of deep learningimage processing in order to overcome the difficulties in cell boundary segmentationgrade definition,provides a cell-based IHC staining intensity gradingquantification capability. The proposed method serves as a useful assistive tool for physicians in performing accurate staining quantification in tissue microscopic images. In addition, it analyzes panoramic pathological images in order to determine the factors most strongly associated with likely disease recurrence."