The proposed technology employed gold nanoparticles (AuNPs) to enhance the sensitivity to achieve PCT rapid detection. The fabricated sensors comprise of suspended glass planar waveguides on glass substratesare integrated with microfluidic channels without vacuum-less processes. The results show good performance with a LOD of 0.871 fg/ml for PCT detection modified. The fabricated sensors show very promising results with a high throughput, enabling mass production for rapidsensitive bio-detectionalso fulfils POCT requirements.

We have developed a low-costportable reader for thermometric lateral flow immunoassay (TLFIA) using colloidal goldlatex beads as reportersa continuous-wave green laser as the heating source. Instead of using infrared cameras, a single-element infrared sensor is employed for temperature sensing without compromising the sensitivity of the reader. The thermometric assay provides a 10× higher sensitivity than color visualizationthe results are sufficiently quantitative to support decision making in point-of-care testing for infectious diseases (such as COVID-19).