In order to improve the disease-selectivitysafety of antibody drugs, we use the autologous hinge as an antibody lockuse protease substrate peptide as linker to generate pro-antibody. Only in the disease area, the overexpressed protease will restore the function of the antibody. The antibody lock can improve the safety of antibodiesthe quality of patient medications. This technology has global patents (granted in 15 countries)technology transfer experience. We believed that the universal antibody lock will bring a revolutionary breakthrough in antibody drugs.

The Hospital has been investing in rural health care for a long time, providing community intelligence testing equipment on the health care side, providing health care workers to take the measuring equipment with them for real-time measurementdata uploading,providing home physiological measuring equipment, allowing people to take measurements at homeupload the values to the system immediately to achieve personal health management functions. It is hoped that this will reduce the workload of the health center staffprovide interactive health care services to local residents.

The novel drug-eluting contact lens is a great substitute for traditional eye drops, which are plagued by problems, such as low drug administration efficiency, discomfort,repeated dosing. Drugs can stay on the eyeball for a sufficient period of time. Patients can have access to treatment in an appropriate state at any time. With these advantages, the novel drug-eluting contact lens is expected to become a new method for the treatment of ophthalmic diseasesfor the recovery of patients after ophthalmic surgery. It has broad application prospects in the treatment of ophthalmic diseases.

We have developed the device recorded the neuronal action potential of multiple mouse brainstheir cerebellum with high sampling rate (30 kHz)multiple channels to accelerate the study of the pathogenesis of neurodegenerative diseases. The team hopes to extend the multi-channel BCI devicebrainwave technology to more neurodegenerative disease biomarker analysis to help pharmaceutical companies to explore the pathogenesis of neurodegenerative diseaseshelp in new drug developmentclinical diagnosis.

This product is a novel risk assessment tool for carotid artery stenosis and stroke. This is a revolutionary healthcare technology using motion analysis and quantification to extract information from pulses for risk assessments. The entire process is completed by taking a short video clip aimed at the neck with only one simple click on any mobile devices or our apparatus, anywhere, anytime. In less than five minutes, the user receives an evaluation report indicating low to high stroke risk. Our product accuracy stands higher than 90% when compared to the clinical outcome. The future indications of this product can be extended to arrhythmia, venous fistula obstruction, etc. This product has the great potential to achieve our dream of “personalized mobile hospital” in the future world.

The principle of the image-based AFib discriminating system is based on the consistency that irregular cardiac cycles can both be detected on the waveforms of electrocardiographyrPPG. The quantity of the blood varies from time to time is captured by a general camera. Signals from RGB channels are then synthesized through the core algorithm to eliminate noisegenerate stable rPPG signals. The processed signals are then classified as AFibnot by a sample-size model. According to the IRB evaluation in En Chu Kong Hospital, the AFib can be well detected with an accuracy of 97.1.

Endometriosis is a serious gynecological disease with a global incidence of 10. This disease will have a serious impact on women’s daily lives, including severe abdominal pain, massive organ bleeding, sexual behavior difficulties, infertility,even high-risk cancer progression. We discover that the karyotype variation of ribosomes is closely related to the deterioration of endometriosis. We collaborate with Hospital on human clinical trials to develop in vitro diagnostic devices that can screen early stage of Endometriosis. It can avoid unnecessary riskscosts of discovering diseases.

The screening kits were developed using miRNAs for high-risk populations for urothelial carcinoma (UC). Products 702703 are designed for chronic kidney diseasehemodialysis patients using urineblood samples, respectively. With high accuracyminimal invasiveness, the kits are intended to be used as a screeningregular monitoring of UC. If a test reveals a positive result, the patient then undergoes cystoscopic examination for further confirmation. Otherwise, the patent only needs to be monitored annually.

We constructed a model to differentiate different neurodegenerative diseases by using blood-based biomarkers. Linear Discriminant Analysis (LDA) was used to reduce dimensionsMICE (Multivariate Imputation by Chained Equations) was used for missing value treatmentchoose CART model to predict missing value imputation. This machine learning model would be used for early dectection of neurodegenerative diseases.

"We present here a portable device with isothermally mediated loop amplification (LAMP) for the diagnosis of infectious diseases. The main components included (1) roller conveyor, (2) hotplate,(3) temperaturemotion control panels. After mixing all the solutions by rollingsqueezing the sealed compartments, the LAMP strip was heated for 30 min for amplification. Finally, fluorescence results can be read with the naked eyeon a smartphone under the UV lamp. The 700g device is powered by a portable charger, making it easier to detect pathogens in resource-limited environments."

Within 10 years, Taiwan will become a super senior society with the proportions in silver hairs of more than 20. Thus, a high-throughputsmart platform with bio-physiology-marker panels is developed for PD progression by combining the bio-medicalphysical sensors, SPRsmart circuit design, leading to a new UPDRS for a more accurateearly diagnosis of a physician.

Swelling at the extremities of the extremities is quite common in KD,it is one of the five major diagnostic criteria for KD. According to the results of our research, about 90 of the children will have this symptomis the most important symptoms of KD suggested by American Heart Association. Our research also found that albumin decreased,the degree of reduction is obviously positively related to the severity of the disease, so we have developed a theory that can detect water, hemethe optical method of oxygen. Provides a non-intrusive method for quick differentiation.

The technology is video-based blood pressure monitoring which will help people know the continuous BP status in real time. Also, the contactless measurement can make a daily health record. We have conducted clinical trials in hospitalsestablished a large database to optimize AI solution. The system joins the physicians＇ specialty to analyze the users＇ health status with AI,takes care of human life with technology.

To develop a potential preservative from microorganisms, Aureobasidium pullulans was the positive candidates. In a laboratory scale, we introduced the Aureobasidium pullulans broth into a practical delivery chain to simulate the commercial process. For disease severitybanana degreening, the results indicated we could obtain a better consistencylonger storage time for exports as well.

The interpretation of next generation sequencing is a big challenge. In order to improve the molecular diagnosis of the patient, we developed the AI_Variant prioritizer, a machine learning based variant prioterization system that can help to prioritize candidate variants for human disease. This module highlighted the possible disease causing variants to help clinician to increase the disease diagnostic yield and decrease the load of manpower.

This technology is used micro-electro-mechanical systems combined nanomaterials and micro-heater systems, because the interdisciplinary integrated manufacturing technologies are used to make miniaturized sensor elements, which are equipped with bluetooth functions of algorithms and detection devices to monitor the ketones gas concentration during patient breathing applied in healthy care.

The HeaortaNet is developed by the TW-CVAI team. The HeaortaNet is a deep learning model trained by 70,000 axial images from 200 patients with verified annotations of the pericardiumaorta. It shortens the time for data processing from 60 minutes, by manual segmentation of both pericardiumaorta, to 0.4 seconds. The segmentation accuracy, as assessed by dice similarity coefficient, is 94.8 for the pericardium,91.6 for the aorta. The imaging-based Cardiovascular Risk Prediction module was constructed by analyzing data from the National Health Insurance Databank.

Our studies showed the endophyte Burkholderia 869T2 help banana to stand against the Panama diseaseimprove growths of pumpkin, cabbage,other crops. The 869T2 helps plants cope with salinity stresscan decrease dioxin accumulations in plants. The specific metabolite PQQ of 869T2 benefits host plant growths. The beneficial endophytethe metabolite can be developed as an protective endophytic agent.

In Taiwan, there are almost 96 million people look for medical treatment due to diabetes. The project successfully used the infrared light measurement system to observe the differences between the bilateral feet,collocating with the Chaos Synchronization to measure the differences between different signals, to decrease the probability of the attendance as the ultimate objective .

Atemoya is a perishable fruit with highly sensitive to chilling injury, which impedes its long-distance trading. This technology integrated reducing field pathogen infections, improving precooling efficiency,utilizing controlled atmosphere transport technology. We successfully prolonged storage life of atemoya to 3-4 weeks. The pilot tests demonstrated that the fruits have been successfully shipped to Kuala Lumpur, Dubai,Canada. The arrival salability was over 90 with 7 day shelf life. We recommend to apply this technology if atemoya will be transport for more than 10 days.

Our team has developed technology to build lung-on-a-chip with the aim of creating alternatives for animal researchachieving more accuratereliable preclinical experimental data.The chip＇s rapideffective screening ability will help the clinical community to reduce costsdrastically shorten the drug-development process.

This project designs a biomedical theranostic chip for neural disorders. It can not only function as an implantable device for treating the Parkinson＇s disease, depression, dementia, but also monitor physiological signals in wearable devices. For the development of medical device, the NeuLive system based on the microchip can accelerate the pre-clinical data collectionverification.

This system provides multiple functions for digital slides, allowing users to complete all tasks without switching between different software systems. The functions include, Project management, Image management, Annotation, Zoon In / Zoom Out view, Navigation view, Category shortcuts, Authority management,Annotation overview.

Supramolecular nanoparticles is a convenient, flexible,modular synthetic non-viral gene delivery vehicle for drug/gene delivery. The self-assembly of SMNPs is enabled upon mixing three different molecular building blocks, namely CD-PEI, Ad-PAMAM,Ad-PEG via Ad/CD motif-based molecular recognition. This allows modular control over the sizes, surface chemistry,payloads of SMNP vectors, thus holding promise for diverse therapeutic applications, especially for developing nanoparticle-based gene delivery platforms.

The sweet pepper cultivationplant protection robot developed includes three parts: the intelligent image identificationpositioning system of sweet pepper diseasesinsect pests is composed of YOLO4 deep learning modelimage 3D vision integration. It can perform disease detectionspatial positioning,guide the robotic arm spraying device to accurately spray the diseased. The automatic walking system can use GPS to plan the movement path of the plant protection robot in the field, search for plants infected with pestsdiseases,perform the tasks of pest control.

The technology aims to develop an AI-based integrated system for emotional detections (anger, sadness, happiness,neutral)multimodal physiological signals (ECG, EEG,PPG),apply to patients with cardiovascular disease. Patients monitor their emotionalphysical statusadminister bio-neuro-feedback to improve their well-being, track disease progression,prevent adverse prognosis.

With the use of E. coli expression system, capsid protein assembly in vitro, X-ray photoprotein crystallographycryo-electron microscope, the T=3 capsid structure of white tail disease viruses for shrimps has been resolved successfully, such that an entire model for capsid structure of virus could be provideda mechanism for viral assemblyinfection could be understood.

The technology provides a new experience for remote respiratory rehabilitation care,let patients realize self-health management at home. The system has three characteristics: First, daily home pulmonary function tests to achieve early warning of disease. Second, the design of automatic feedback aperture valve provides the best positive expiratory pressure (PEP)for pulmonary rehabilitation,APP helps user to do breathing exercise. Third, electronic monitoring of inhaled medications with a two-way flow sensor module,APP helps user to guide the inhalation process.

We originally design a highly efficient NdYVO4/KGW Raman laser at 579.5 nm. The KGW crystal is specially coated to prevent the Stokes wave from propagating through the gain medium so as to minimize the cavity losses. Moreover, we explore a new output coupler with double-sided dichroic coating to exterminate the leakage power of the Stokes wave to lead to a remarkable improvement for the output efficiency. The maximum output power can be up to 10.5W at a pump power of 40W. The conversion efficiency of the diode pump light to yellow laser output can be increased to 26.3.

Here, we introduce an electricity-free centrifuge platform based on a manual centrifuge. The provided centrifugal force is sufficient to produce a plasma purity of 99 separated in as little as 2−3 min. We then performed an immunoassay on a paper devicethe results were observed by a portable reader. As a result, the detection limit of the C-Reactive Protein is 1 ng/mL, with a total turnaround time of 7 min.