We have synthesized the LiYF4:Ce3+ nanoparticles – Methotrexate (MTX), targeting pancreatic cancer cells via folate receptors. Under ultralow 0.1 Gy X-ray irradiation (the lowest dose in the world, for 2-3 times), the nanoparticles can exhibit radiosensitization effect,radiosensitizing chemotherapy, because of MTX released by X-ray inducing photocleavage of NPA linker. The dual sensitization effect will enhance ROS production, DNA damage, cell cycle S phase arrest in pancreatic cancer cells. We have also demonstrated the excellent efficacy in AsPC-1PANC-1 xenografted pancreatic mice.

Prof. Chen＇s research team at IPT NTHU achieved a breakthrough to build table-top coherent EUV light source. This new accessiblereliable EUV light source makes a lot of the first possibilities, enabling the dynamics of chemical reactions, nano-materialsbio-molecular systems to be studied with unprecedented temporalspatial resolution, e.g. coherent 13.5nm EUV light source for nm-scale defect inspection.

AI model is consisted of detection, data pre-processingclassification ensemble model. We applied YOLO 3 to detect vertebral body from radiography,used data pre-processing to reduce image noisyenhance contrast, integrated ResNet34, DenseNet121, DenseNet201 into AI mode. Our result reveals the ensemble model has better performance in accuracy, sensitivityspecificity.

In CB-XLCT imaging, when nanophosphors are delivered to tumor tissues,irradiated by X-rays, luminescent light with wavelength range of 500-700 nm will be exciteddetected by optical camera from different directions. After reconstruction, it can provide tumor locations. The micro-CT subsystem also provide X-rays to excite nanoparticles for luminescence tomography.

Metal-organic framework is a kind of regular porous material which is self-assembled by metal ion centerorganic ligand framework. I used the metal-organic framework as a templateprecursor to successfully develop a low-cost bimetallic phosphide, which exhibits excellent water splitting hydrogen production performance. The on-site real-time change experiment technology provided by Taiwan Photon Source is a great weapon for real-time detection of active sitesreaction centers during the development of key catalyst materials.

Combined the advanced synchrotron beamline with the in-situ processing technologiesthe diversified measurement systems, we provide a parametrizable AI platform for material manufacturing processes, microstructures,product performance.

The long trace profiler (LTP) can be used to measure the figureintermediate frequency roughness of an X-ray mirror. The measurement process is accurate, high-speednon-contact. The radius of curvature for the measurement may be ranged from a value from 5 m to infinity, such that the surface profile feature can be measured in the range with a longitudinal resolution of 0.15 nm.

With the use of E. coli expression system, capsid protein assembly in vitro, X-ray photoprotein crystallographycryo-electron microscope, the T=3 capsid structure of white tail disease viruses for shrimps has been resolved successfully, such that an entire model for capsid structure of virus could be provideda mechanism for viral assemblyinfection could be understood.

The chromium-doped zinc gallate, ZnGa2O4:Cr3+, material is viewed as a long-lasting luminescent phosphor which can avoid tissue autofluorescence interference for in vivo imaging detection. The cubic ZGC revealed a specific accumulation in liver0.5 Gy used at the end of X-ray excitation was sufficient for imaging of deep seated hepatic tumors.

“MeDA OXR: Real-time Hazard Recognition System,” which can automatically screeninterpret the medical images in real-time, is designed for emergency rooms to assist physicians in diagnosis, reducing medical risks,improving overall efficiency. Combining portable X-RayAI algorithms, the system performs real-timeaccurate preliminary screeningdiagnoses of diseases, such as pneumothorax, pneumonia,tuberculosis. It can also locate the nasogastric tube, endotracheal tube,central venous catheter, while misplacement of that is sent to the physicians when detected.

X-ray diffraction technology is used to analyze the drug efflux pump, ST50, form S. Typhi. The drug efflux mechanism for multiple drug resistant (MDR) S. Typhithe potential location for antigen of market-based typhoid detection reagent are understood through this ST50 structure. It could help develop the more effective typhoid detection reagentthe new antibiotics against MDR S. Typhi.

(1) High flux mode for integrated measurements of SAXS/WAXS/UV-Vis-absorption/Refractive-index/Multi-angle-light-scattering (MALS) with an online high-performance liquid chromatography (HPLC) instrument, suitable for exploring biomacromolecular solution structures of a wide length scale and structural kinetics down to microsecond time scale. (2) Ultra SAXS (USAXS) mode for resolving hierarchical structures of bio-machinery assembly up to a few um length scale. (3) Anomalous SAXS mode for metal or mineral distributions (including calcium) in bio organelle or drug carriers. (4) Microbeam SAXS/WAXS mode for structural mapping of the textures or specific infected cells in natural/synthetic bio-tissues, organelles, or biomaterials.

1.High flux mode for integrated measurements of SAXS/WAXS/UV-Vis-absorption/Refractive-index/Multi-angle-light-scattering (MALS) with an online high-performance liquid chromatography (HPLC) instrument, suitable for exploring biomacromolecular solution structures of a wide length scalestructural kinetics down to microsecond time scale. 2.Ultra SAXS (USAXS) mode for resolving hierarchical structures of bio-machinery assembly up to a few m length scale. 3.Anomalous SAXS mode for metalmineral distributions (including calcium) in bio organelledrug carriers.