A flexible PPG sensor patch for measuring pulsations of blood vessels estimating ambulatory blood pressure monitoring (ABPM). The measured quality PPG signals are analyzed to estimate blood pressure (BP), heart rate (HR), blood oxygen (SpO2)atrial fibrillation (A-Fib)avoid motion artifacts. In this way, with subject’s physiological condition apprehended accurately.

This successful technology is the digital interventions on depression patients based on (1) heart rate variability bio-feedbacks (HRVBs) measured by a novel flexible sensor patch attached on patient’s wrist(2) an APP. An innovative flexible low-power PPG patch has been designed which is capable of providing weeks of high-quality PPG signals which are essential towards accurate estimation of HRV for favorable efficacy of designed digital interventions. Also, An AI model correlating the HRVsand PHQ-9/HDRS scores of depression patients will be built based on collected data.