"The IHC staining intensity grading algorithm combines a series of complementary processes of deep learningimage processing in order to overcome the difficulties in cell boundary segmentationgrade definition,provides a cell-based IHC staining intensity gradingquantification capability. The proposed method serves as a useful assistive tool for physicians in performing accurate staining quantification in tissue microscopic images. In addition, it analyzes panoramic pathological images in order to determine the factors most strongly associated with likely disease recurrence."