Novel alloys are composed of five special technologies (1)Development of CALPHAD phase diagram for medium entropy alloys(2)Development of novel lightweight Ti-rich medium entropy alloys with high strengthhigh ductility (YS 950 MPa, TS 1200 MPaEL 30)(3)Heterogeneous structures obtained by the thermomechanical treatment an rapid annealing treatment(4)Tailoring the heterogeneous structures to enhance the mechanical properties (YS 1240 MPa, TS 1510 MPa, 250 MPa·cm3/ga nd EL 25)(5)Commercial productions are produced by these large dimension alloys for further industrial application.