Our research team has developed a short-wave infrared light gold nanoclusters as an intraoperative fluorescent imaging agent, breaking the light emission limit of the previous gold nanoclusters, shifting the light emission position to the infrared spectrum, successfully avoiding the autofluorescence between the tissuesachieve deeper penetration along with instant bio-imaging. This technology has clearerdeeper imaging benefit with the potential to become a clinical medical infrared imaging agent.