Despite the progress of medical technology, recurrent pregnancy losspremature birth are still a vast problem. One of the main reasons for these complications is cervical insufficiency. Although cervical cerclage is considered to be the standard method for preventing premature birth, it is an invasive procedure that requires anesthesiasurgical techniques, so it cannot be popularized among the pregnant population. The novel “non-invasive cervical ring” medical device has been developed to meet clinic needs for prevention of preterm labor due to cervical insufficiency.

Our brain waves consist of a lot of nonlinear characteristics. Holo-Hilbert cross-frequency phase clustering (HHCFPC) is a cross-frequency coupling connectivity analysis based on the nonlinear Holo-Hilbert Spectral Analysis (HHSA) method. It is achieved by clustering the vectors of "phase difference" between the phase of a first layer IMF (obtained by HHSA) from one EEG channelthe phase of a second layer IMF from the other EEG channel. The results of HHCFPC can be used as a guide to optimize the parameters (e.g. frequency,frequencydepth of AM) of non-invasive brain stimulations.