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    • Develop of novel anti-diabetic agents via targeting endogenous lipid mediators

      Bio-tech & New Drugs FutureTech Develop of novel anti-diabetic agents via targeting endogenous lipid mediators

      PPARγ is the master regulator of glucose metabolism.15-keto-PGE2 is an endogenous PPARγ ligand whitch is degraded by ZADH1. We found that increasing 15-keto-PGE2 promotes glucose uptake. We identified several ZADH1 inhibitors which could increase 15-keto-PGE2 promote glucose uptake via activating PPARγ. Our results showed that inhibition of ZADH1 is a novel approach to treat type 2 diabes mell
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