By collecting the changes of kinds of vital signs(including heart beat / blood pressure / steps), we combined the results with the testers’ fatigue scores which belonged to the matched fatigue typestheir basic profiles. We extracted 780 types of structural features sets by cleaning raw data, then separating into training set, validation settesting set. With machine learning algorithm to auto-optimize regression analysis, finally we come out the correlative features between vital signsfatigue ,the overwork model as our deliverables.