Ninety percent of human diseases are related to abnormal inflammation. WJM team has successfully developed a new monoclonal antibody that can inhibit a key inflammation protein. Animal experiments have accumulated more than ten disease modes, including a variety of solid tumors, fibrosis, degenerativecardiovascular diseases. This antibody is qualified as an orphan drug for the treatment of IPF. New coronary pneumonia has greatly increased the demand for pulmonary fibrosis treatment,has also become an important target for mergersacquisitions of global pharmaceutical companies.

Taiwan faces a major water shortage crisis in 2021. Hydrogel as a commercial soil conditioner has the potential to improve soil propertiesreduce water scarcity in growing plants. This technology discovered that environmentally responsive cellulose-based hydrogels have the potential for use as soil conditionersas controlled release devices in horticultureagriculture. Waterfertilizer soil conditioners can be manufactured based on the ecological recycling process. In the future, technology can develop other carriers that require the controlled release of active ingredients.

This is a regenerative biomedical technology, which aims to address the human chronic lung diseases that currently has no pharmaceutical approach for efficient controltherapy, such as COPDlung fibrosis. The principle is to induce the in vivo reprogramming of endogenous alveolar epithelial cells through activation of stemness factor BMI1, which potentiates the repair of injured tissues.

"The designed ultrasound gel is modified with nanocrystalnanofiber. The product is designed to be sterilizablefits well to the ultrasound probe. With such nanomaterials, our product shows great ultrasound transmission abilityenhanced mechanical strength. The highlights of the this ultrasound agent include: (1) Enhanced compressibilitytensile strength with adjustable composition. (2) Improved infection controlreduced risk of complication. (3) Improved transmission depth with certain thicknessimproved image quality within superficial region."

We have successfully synthesized NSC828779, a new salicylanilide derivative,demonstrated that this new compound bears high efficiencylow toxicity on: [1] inhibiting renal fibrosismononuclear leukocytes infiltration[2] inhibiting IL-36α signaling, on renal fibrosis in a mouse renal fibrosis model. Importantly, we also owned [1] three approved material patents (US 8975255 B2 US 9162993 B2 I454445, Taiwan) [2] two indication patents [US 17/308,67, USPTO, USA,T2393-TW, NDMC, Taiwan, submitted) under review [3] technology transfer to Encommelt Medical Sciences llc.

In this work, we developed a one-step process for synthesizing carbon nanofibers encapsulated Ni magnetic nanoparticles. The process for CO2 converted to solid carbon can be applied in many fileds

The technology provides a new experience for remote respiratory rehabilitation care,let patients realize self-health management at home. The system has three characteristics: First, daily home pulmonary function tests to achieve early warning of disease. Second, the design of automatic feedback aperture valve provides the best positive expiratory pressure (PEP)for pulmonary rehabilitation,APP helps user to do breathing exercise. Third, electronic monitoring of inhaled medications with a two-way flow sensor module,APP helps user to guide the inhalation process.

Our previous studies suggested that increase Cisd2 levels may attenuate the pathogenesis of NAFLD/NASH. Accordingly, potent Cisd2 activators with the capacity to enhance Cisd2 levels were identified through the screening of skeletally diverse collections and structural optimization. So far BPRCD0001S0 is the most potent Cisd2 activator obtained, which has been studied extensively. Data obtained revealed that BPRCD0001S0 has no detectable toxicity in vivo, can activate Cisd2 in liver and ameliorate obese-related and fructose-induced NAFLD/NASH.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

Our team integrates microwave engineeringtraditional textile technology to develops a new microwave dyeing technologyequipment that can quickly dye without heating with a boiler for synthetic fiber. Therefore, it can achieve zero exhaust emissionsshorten the dyeing hours. This technology is highly compatible with most fabrics on the marketup to 4000 dyescolors. In addition, it can build a green supply chain reputation for the textile dyeingfinishing industrymass-produced textile dyeingfinishing technology.

Combined the advanced synchrotron beamline with the in-situ processing technologiesthe diversified measurement systems, we provide a parametrizable AI platform for material manufacturing processes, microstructures,product performance.

A wearable sweat sensing device is developed for health monitoring during exercises to prevent illness caused by fluid losses. By biomimetic designchoosing material with high permeability, the sweat collector possesses high sweat collection efficiency, rapid transportlow response time. Inside the channel, salt concentrationsweat rate is deduced by electric property analysis. Finally

The time-temperature indicator (TTI) developed by immobilizing laccase on electrospun fiber film with high specific surface area. The activation energycoloration of laccase TTI can be adjusted by pHaddition level of laccaseNaN3. This TTI exhibits high accuracy, stability, temperature reversibilitylow cost. The intelligent food packaging developed by this TTI can reduce the food wastethe food safety risk in traditional packaged foods.

“Aerogel Cold Chain Storage Box with High-efficiency Thermal Insulation Performance” insulation layer includes phase change materials aerogel phenolic foamed insulation materials,aerogel insulation coatings. The carbon fibre used composite materials as the box shell. It is an innovative vaccine mobile refrigerator that does not require a power supply. It can keep cold for a long timehas good low-temperature stability. Our thermal materials have better cold retentionfire resistance than the insulation material used in the international COVID-19 vaccine storage.

We developed our very own battery management system as well as improved the battery infrastructure, ensuring higher voltage as well as better safety we completely redesigned the suspension system, monitoring different dynamic performances via individual shock absorbers we also used the lighterstronger carbon fiber as the material for our wishbones.