Endometriosis is a serious gynecological disease with a global incidence of 10. This disease will have a serious impact on women’s daily lives, including severe abdominal pain, massive organ bleeding, sexual behavior difficulties, infertility,even high-risk cancer progression. We discover that the karyotype variation of ribosomes is closely related to the deterioration of endometriosis. We collaborate with Hospital on human clinical trials to develop in vitro diagnostic devices that can screen early stage of Endometriosis. It can avoid unnecessary riskscosts of discovering diseases.

An innovative ointment solves an unmet clinical need to cure keloid wounds The composition of the ointment can precisely modulate the cell functionsgene expression of keloid fibroblasts, making them close to the performance of normal fibroblasts. Thereby, when applying the ointment to keloid woundsthe human body prone to the formation of keloid wounds, the wound is smoothed, healing close to normal skin.

The RL model develops a control policy directly from experience to predict statesrewards during a learning procedure. Hence, we designed a medical image environment including US images, different actions,rewards, agent learns in this environment to extract the ALN regionevaluates the status. The performance of our proposed method achieves an accuracy of 83.6, a sensitivity of 88.6,a specificity of 89.0.

This project will establish a National biobank consortium of Taiwan through the fund support from the government. The National Health Research Institutes will establish a Central Office for the collaboration works, which includes collecting the number of samples of the human biological database in each biobank that agreed to join the Consortium. All Alliance need to follow the same SOP for the collection processthe quality of the biosample. Adequateconsistent clinical data will also be established under the Information Security Management Treaty. Since the contents of the biobanks from different institute are quite different, we will be able to quickly establish a largecomprehensive biobank network.In line with the need of biotechnologypharmaceutical industries.

Epidermolysis bullosa (EB) is an inherited blistering skin diseaseis also one of the most "urgent, severe, difficultrare" diseases. Since there are at least 21 disease-causing genes involved in EB with markedly variable manifestations, it is particularly difficult for accurate diagnosis. In recent years, next generation sequencing (NGS) has been widely applied in the genetic diagnosis of rare hereditary disorders. The EB team in NCKU established the protocol of EB diagnosis by combining NGSvarious tools of pathologymolecular studies. Till now, we have completed the genetic diagnosis for more than 50 Taiwanese EB patients.

This project proposes a smart contact lens ideally capable of simultaneously observing the tear evaporation rate, the tear osmolarity,the ocular surface temperature. To solve the shortcoming of the current difficulty in quantifying DES, assist doctors in the diagnosis of dry eye conditions, the effectivenessselectivity of drugs, the treatment statusrecovery level.

Surface-enhanced Raman spectroscopy (SERS) is a useful analytical technique for detecting extremely small amounts of molecules. Herein, we designed a paper-based quasi-three-dimensional SERS substrate (P-SERS) that can provide potential to improve Raman analyses for food safety, pesticide poisoning, precision medicine, drug abuse and DNA/RNA testing. The sensitive, low-cost, flexible and disposable SERS substrate could be easily fabricated by physical deposition of gold nanoparticles array onto a filter paper. In this case, we are able to create non-continuous Au islands on the fiber surfaces, where the gaps between AuNPs can dramatically generate the high electric field to enhance Raman signal of target molecules.

In the current of study, cell subsets, cell proportionsthe immune function of tumors-infiltrating leukocytes were used to indicate the features of tumor immune microenvironment in non-small cell lung cancers (NSCLCs) with different type of EGFR genetic alteration.