1. Infrared wax physisorption kinetics (iR-WPK) provides a glyco-histopathological imaging analysis for examining tissue sections, which utilizes n-alkanes with carbon number (CN) from 20 to 34 and beeswax as glycan adsorbents for targeting similar longitudinal length of glycans of glycoconjugates anchoring in the cell surface. 2. It is an in-situ non-destructive method of examining tissue sections for cancer screening and prognosis prediction for chronic kidney disease by profiling aberrant glycans covalently-attached to both glycoconjugates anchored in tissue sections. 3. It can screen ten cancers including colon cancer, breast cancer, ovary cancer, cervical cancer, oral cavity cancer, gastric cancer, skin cancer, prostate cancer, intestinal neuroendocrine tumor and brain cancer.

Two COVID-19 animal models, including humanized Ace2 micehuman peripheral blood lymphocyte transplanted mice, are used to mimic COVID-19 infection, immune responsecytokine release syndrome in human. The immune analytical platform can further outline the immune cell, cytokinebiomarker response pattern after viral infection. The COVID-19 humanized animal modelthe immune analytical platform will support COVID-19 related researchfacilitate new drugnew therapy validation.