This proposed technique aims for solving the key challenge in the chemical, pharmaceutical,biomedical raw material industries: how to develop effectiveeconomically feasible downstream processing. We presented an integrated continuous extractionphase separation reactor, which consist of a unique helix wire to precisely control the liquid-liquid interface. It provides R&Dindustry with a complete solution at production sites to quickly screen downstream processing with different permutationscombinationsgreatly reduces time costsexpensive materials used.