Swelling at the extremities of the extremities is quite common in KD,it is one of the five major diagnostic criteria for KD. According to the results of our research, about 90 of the children will have this symptomis the most important symptoms of KD suggested by American Heart Association. Our research also found that albumin decreased,the degree of reduction is obviously positively related to the severity of the disease, so we have developed a theory that can detect water, hemethe optical method of oxygen. Provides a non-intrusive method for quick differentiation.

The developed multi-functional bio-sensor chip has the advantages of excellent detection performance, wide application,low mass production. At present, we have already cooperated with upstreamdownstream manufacturers for mass production of the multifunctional bio-sensor chips. At the same time, cooperate with the instrument manufacturer to develop a simple portable electrochemical detect

Through combining the cutting-edge technology of TD-ESI/MS to its comprehensive database library of toxicants, a fast-track toxicant analytical platforma set of standard operating procedures are developed that enables the emergency physicians to access correct toxicological information within a short turnaround timerescue the poisoned patients based on accurate laboratory data.

Integrated Taiwan＇s superior industries such as semiconductor manufacturing processes, precision micro-molding, hot embossing,chip packaging to develop Pt/Au nano-alloy electrodes with applications in neutral non-enzymatic glucose biosensorsneutral non-enzymatic glucose biofuel cell. This novel Pt/Au nano-alloy electrode possesses advantages of technology foresight, good detection perfor

X-ray diffraction technology is used to analyze the drug efflux pump, ST50, form S. Typhi. The drug efflux mechanism for multiple drug resistant (MDR) S. Typhithe potential location for antigen of market-based typhoid detection reagent are understood through this ST50 structure. It could help develop the more effective typhoid detection reagentthe new antibiotics against MDR S. Typhi.

The technology of 「Guard Patch」includes three parts. 1. Wearable devices, 2. Intelligent wireless monitoring system. 3. Cloud server with AI to avoid the happen of cardiovascular diseases (CVD). The products of 「Guard Patch」also includes three parts: 1. Medical Market: (1) YuGuard, (2) YuSound, (3) YuRine. 2. Wearable Market: (1) YuCloth, (2) YuPet, (3) YuBelt. 3.Educative Market: TriAnswer. The mentioned seven products developed by Yutech can be employed in medical, wearable, educative markets to satisfy the different demands of customersachieve the dream of 「Bioelectronics Garden」

We based on ion trap for mass filter so that ultra-high vacuum is not needed to reduce the weightsize. We took frequency scanning to increase our mass range by 10,000,000,000. We used LED as LC detector to reduce sizecost. Therefore, we not only made a portable device but also a device with many special advantages in technology. An advanced analytical lab can become mobile to easily reach anywhere which needs in-situreal-time analysis by our inventions.

We invented a non-destructive terahertz (THz) deep-learning computed tomography system based on time-domain spectroscopy. In the method, THz time-domain signals are profiled. Multiple features are retrieved from those profiles by a trained modeltransformed to the spatial domain to reconstruct a cross-sectional tomographic image. We have also invented a 3D THz tomographic system based on multi-scale spatio-spectral feature fusion in a multi-scale manner. We believe our work will stimulate further applicable research of THz tomographic imaging with advanced computer vision techniques.

EPICAn is a novel technique that uses liquid biopsy for epigenetic analysis. Using methylation-specific PCR method to analyze specific gene methylation of cell-free DNA in plasma for early detection of breast cancer. The advantages of this technology are 1. High accuracy 2. Low false positive rate 3. Low-invasive 4. less limitation 5. Available for routine continuous detection 6. Monitoring cancer changes 7. Aided diagnosis 8. Automated process 9. Easy-to-operate 10. Rapid analysis. It is expected that EPICAn technique can increase the accuracy of early detection of breast canceraid clinicians diagnosis.

We use features such as asymmetric expression and crooked eyes to assess the risk of facial stroke. Observing the micro vibration of the head caused by the contraction of the heart, and develop a zero-contact facial heart rate and respiration rate detection technology in conjunction with the camera. The technology can accurately measure heart rate and respiration rate in real time, thereby reducing the risk of infection. This technology has obtained two ROC patents (M590433, I689285), two US patents (HEART RATE DETECTION METHOD AND DEVICE THEREOF,MOUTH AND NOSE OCCLUDED DETECTING METHOD AND SYSTEM THEREOF). The possibility of detecting strokes through AI machine learning methods is not only accurate, but also find out signs of stroke early to grasp the best time to seek medical treatment.

Surface-enhanced Raman spectroscopy (SERS) is a useful analytical technique for detecting extremely small amounts of molecules. Herein, we designed a paper-based quasi-three-dimensional SERS substrate (P-SERS) that can provide potential to improve Raman analyses for food safety, pesticide poisoning, precision medicine, drug abuse and DNA/RNA testing. The sensitive, low-cost, flexible and disposable SERS substrate could be easily fabricated by physical deposition of gold nanoparticles array onto a filter paper. In this case, we are able to create non-continuous Au islands on the fiber surfaces, where the gaps between AuNPs can dramatically generate the high electric field to enhance Raman signal of target molecules.

PCR, a gold-standard diagnostic method, were labor-intensive, time-consuming,costly, which restricted its application to widespread screening. Herein, this study purposes a one-potnon-washing method to rapidly detect virus by dual-SERS mechanism. COVID Antigens were captured by SERS nanoparticlesnovel SERS substrate simultaneously to achieve 6 order enhancements within 20 minutes. The dual-SERS sensors have reached a detection limit of 1 ng/ml in clinical samples for recognizing nucleocapsid & Spike proteins of COVID-19, which is comparable with PCR results.

The DNN models of this technology include a LithoNet, an OPCNet,a layout novelty detection network. LithoNet is a learning-based pre-simulation model for layout-to-SEM contour prediction,OPCnet is a dual network of LithoNet for photomask optimization. Integrated with a well-trained LithoNet, our layout novelty detection network, consisting of a self-attention guided LithoNetan autoencoder, can check if there are layout patterns easily resulting in local distortions in contours of metal lines based on multi-modal (global-local) feature fusion.

SeraParma™ COVID-19 IgM rapid test has high detection sensitivity, which can provide rapid detection of early COVID-19 infection. This SeraParma™ COVID-19 IgM rapid test can detect whether there are IgM antibodies produced in the early stage of infection (within 7 days of symptoms onset) with one drop of the specimen (serumfingertip blood) in 15 minutes by naked eyes compared with LFIA antibody rapid test. It is worth noting that the SeraParma™ COVID-19 IgM rapid test can accurately detect the patients with positive infection within 7 days of the onset of symptoms compared with LFIA.

The innovative technology which is based on the unique biomimetic material, including immunomagnetic nanoparticles, aqueous extraction solvent,a portable IoT detection device promotes the detection speed, accuracy,precision of the target molecule. Featuring with the excellent ability of non-specific binding, this technology decreased the probability of false-negative/false-positive succe

Laser material recognition technologyintelligent color compensation lighting system, with AUV to realize the function of underwater rust detectionimage color restoration, real-time acquisition of rust information through spectral analysisdisplay of true rust color on the image, so that the algorithm can be accurate Determine the health of the cylinder. The vehicle will establish the health information of the wind turbine to help the inspector make the best maintenance strategymaintain the power generation efficiency of the wind turbine in the best condition.

A phosphate-sensing chip was constructed by a copper phosphate-deposited electrode. The modification of ionic liquidplasticizer can improve the selectivity of phosphate anionsreduce the interference of sulfate, nitratechloride anions. The sensing chip equipped with a portable electrochemical device can directly detect the phosphate concentration of solution extracted from soil samples in ten minutes by using amperometry. The sensing chip promises the feasibility of detecting the phosphate concentration without expensive instrumentlabor-intensively chemical colorimetry.

Here, we introduce an electricity-free centrifuge platform based on a manual centrifuge. The provided centrifugal force is sufficient to produce a plasma purity of 99 separated in as little as 2−3 min. We then performed an immunoassay on a paper devicethe results were observed by a portable reader. As a result, the detection limit of the C-Reactive Protein is 1 ng/mL, with a total turnaround time of 7 min.

Endometriosis is a serious gynecological disease with a global incidence of 10. This disease will have a serious impact on women’s daily lives, including severe abdominal pain, massive organ bleeding, sexual behavior difficulties, infertility,even high-risk cancer progression. We discover that the karyotype variation of ribosomes is closely related to the deterioration of endometriosis. We collaborate with Hospital on human clinical trials to develop in vitro diagnostic devices that can screen early stage of Endometriosis. It can avoid unnecessary riskscosts of discovering diseases.

This rapid diagnostic device for monitoring the abnormal growth of the endometrial tissue is expected to allow women to detect whether VEGFIL-6 are too high at home in a simplerapid manner. These two factors are also increasing in some gynecological cancers. Through the new device, it is convenient for women to self-monitoring women physiologically-relevant diseasespossible causes of abnormal bleeding in the future,seek appropriate medical treatment early.

A portablemagnetic surface Raman-enhanced scattering (SERS) nanoparticle arrays platform would be developed for magnetic separationSERS detection of environmental, water,biomolecules samples. It is very simplerapid platform with portable Raman spectroscopy to detect samples (bacteria, virous, water toxicants) after magnetic separation processes, without labelling the fluorescence dye,the limit of detection concentration is lower than 10-8 M.

We develop a vulnerability detection module to identify three important security vulnerabilities in the IMS system that supports 4G/5G multimedia services. We have validated them in 4 carriers from TaiwanU.S. using smartphones from 7 brands,shown that they can be exploited to launch a stealthy call DoS attack, a social engineering attack with ghost calls,a call ID spoofing attack. Moreover, attackers can detect attackable users using an AI technique with only the users＇ phone numbers. We finally propose solutionsdevelop an AI-based technique of call ID spoofing detection.

The innovative technology is based on the unique biomimetic material, including immunomagnetic nanoparticlesa portable IoT detection device, promoting the detection speed, accuracy,precision of the target molecule. Featuring with the excellent ability of minimizing the non-specific binding, this technology decreases false negative/false positive successfully. The device combines IoTAI module for statisticscalculation on the cloud for building up a magneto-electrochemical IoT sensing system for the integrated isolationprofiling of extracellular vesicles from plasma.

Here we present a portable microfluidic device that can perform immunoassay for infectious disease diagnosis or detect heavy metal ions in water samples. The device is composed of two major components: nanomaterials modified paper-based detection platform and semi-automated flow manipulator. A reusable 3D-printed device is used to hold a disposable detection pad that modified with functional nanomaterials for water quality monitoring or antibodies for disease diagnosis. Besides, the use of spring-containing 3D-printed syringes manipulates a large-volume sample without manual actuation. Meanwhile, by controlling the flow rate via the linked flow regulator at the syringe outlet, solutions can react stably with the paper platform, which provides detection and pre-concentration effects.

This technology is a new microarray chip sensing technology that integrates "organic light-emitting diodes", "liquid crystal chemical sensors" and "mobile communication system" into "multifunctional liquid crystal smart cloud sensors". The obtained signals are uploaded to the cloud for multi-dimensional analysis to achieve multiplex detection in one single sample. This sensor device is lightweight, low-cost, simple to operate, and the target-of-interest can be custom-made according to user needs.

Our inter-institutional research team developed RS-D7, a novel NMDAR modulator/DAO inhibitor as a drug candidate for the treatment of ataxia/MSA. Based upon the core symptoms, we designedapplied preclinical mouse behavioral phenotyping techniquesclinical motor assessments to demonstrate the effectiveness of RS-D7our functional assays. RS-D7 offers multi-symptomatic relief.

"1.Background: The deterioration of lithium batteries leads to safetycost issues. Ultrasonic detection has the advantages of cost, size,immediacy. 2.Detection: Under the control environment, the ultrasonic signal is actuated on each part of the battery,the reflectedtransmitted wave is collected. 3.Analysis: It has methods such as spectrum, image,DL to evaluate the SoH, the distribution of degradation types,the location of faulty cells in the battery module. 4.Theory: Use the acoustic properties of the battery with software simulation to verify the measured data."

"a.The Digital ArchivingConservation System of Cultural Relics combines various imaging techniques like catoptric imaging, 3D renderingmulti-spectral imaging, which provides multiple scientific images data for the inspection of cultural relics. b.Environment Detection System allows controlling the environmental device from a far distance."

"Establish an immunological-based platform for nano drug: 1. Establish macrophages as an in vitro cell-based testing platform 2. Safety assessmentimmunomodulatory effects of nano drugs 3. Gold nanodots as a specific target of Nrf2 pathway against chronic diseases."

(1) High flux mode for integrated measurements of SAXS/WAXS/UV-Vis-absorption/Refractive-index/Multi-angle-light-scattering (MALS) with an online high-performance liquid chromatography (HPLC) instrument, suitable for exploring biomacromolecular solution structures of a wide length scale and structural kinetics down to microsecond time scale. (2) Ultra SAXS (USAXS) mode for resolving hierarchical structures of bio-machinery assembly up to a few um length scale. (3) Anomalous SAXS mode for metal or mineral distributions (including calcium) in bio organelle or drug carriers. (4) Microbeam SAXS/WAXS mode for structural mapping of the textures or specific infected cells in natural/synthetic bio-tissues, organelles, or biomaterials.