Cancer is the first leading cause of death in Taiwan. Targeted therapy allows the cancer cells to be specifically targeted, reduces the side effects,achieves the purpose of precision cancer treatment. This report contains two invention technologies which combined early & specific diagnosis of a specific Aurora-A mRNA isoform in cancers (the companion diagnosis)the treated with a selective locked nucleic acid (LNA)-modified novel double-stranded short interfering nucleic acid (siRNA) to inhibit the translation of this Aurora-A mRNA isoform (targeted therapy) in cancers.

Given its own researchdevelopment advantages of biomedical core facilities, as well as testingverification capabilities, Taiwan Instrument Research Institute (TIRI) provides a one-stop service for medical device R&D teams from prototype counseling to product testingverification. Based on the medical device accelerator platform, TIRI assisted the medical device R&D teams to accelerate the commercialization of their R&D results. Through the Medical Device Service Platform, TIRI helps manufacturers join in combatting the pandemic.

EPICAn is a novel technique that uses liquid biopsy for epigenetic analysis. Using methylation-specific PCR method to analyze specific gene methylation of cell-free DNA in plasma for early detection of breast cancer. The advantages of this technology are 1. High accuracy 2. Low false positive rate 3. Low-invasive 4. less limitation 5. Available for routine continuous detection 6. Monitoring cancer changes 7. Aided diagnosis 8. Automated process 9. Easy-to-operate 10. Rapid analysis. It is expected that EPICAn technique can increase the accuracy of early detection of breast canceraid clinicians diagnosis.

This is a method for identifying single nucleotide polymorphisms (GALNT14 genotypes) of a target nucleic acid for predicting whether a patient suffering from HCC will respond to combination chemotherapy. Accordingly, physicians can decide whether the HCC patients should receive chemotherapyTACE. This method could also predict prognosis in multiple gastrointestinal cancers.

"We present here a portable device with isothermally mediated loop amplification (LAMP) for the diagnosis of infectious diseases. The main components included (1) roller conveyor, (2) hotplate,(3) temperaturemotion control panels. After mixing all the solutions by rollingsqueezing the sealed compartments, the LAMP strip was heated for 30 min for amplification. Finally, fluorescence results can be read with the naked eyeon a smartphone under the UV lamp. The 700g device is powered by a portable charger, making it easier to detect pathogens in resource-limited environments."