We designed a cascade spiral microfluidic device (i-Finity®)continuously isolated the unlabeled cancer cells from blood samples without lysing processes. The results showed that the i-Finity® device excluded a high percentage of RBCs in the first stagerecollected the cancer cells in the second stage. The i-Finity® device can efficiently enrich the cancer cells more than 1000 times in 10 minutes, which substantially curtailed sample preparation timeimproved the accuracy of diagnosis.

Our team has developed technology to build lung-on-a-chip with the aim of creating alternatives for animal researchachieving more accuratereliable preclinical experimental data.The chip＇s rapideffective screening ability will help the clinical community to reduce costsdrastically shorten the drug-development process.

In autonomous driving, LiDAR can clearly distinguish the objectsget the object information such as speeddistance at medium-range (~100 m) for autonomous driving scheme entering Level 3. Therefore, in this study, we combine the reflective optical phased array (OPA) chip1550-nm VCSELs with a photodetector, a ToF chip,a microcontroller to produce an eye-safe, all-solid-state,low cost (less than $100 USD) LiDAR module, which is the world＇s leading LiDAR technologymore cost-effective than the current products for autonomous vehicle market.

Dynamic vision sensors have been investigated to report motion-only images for moving object recognition. Less but essential information helps post-process recognition algorithm reduces computationimproves accuracy. Implement low powerlow latency deep Learning chip based on neuromorphic Intelligence. The neuromorphic obstacle detection algorithm integrates visualproprioceptive signals. The algorithm is characterized by its efficiencylow power consumption. We possess the next-generation in-memory computing AI chipsnext-generation UAV key softwarehardware technology

Lung-on-minilab is designed as a tool for personalized healthcarewill contribute in precision medicine. Here, the tumor microenvironment was reconstituted using liquid dielectrophoresisarranged as lung tissue. The size of pattern can be customized as stages of cancer. Additionally, this chip was equipped a gradient microfluidic channel which enabled testing combination of medications. This is the first device where chemotherapyimmunotherapy medications can be tested together. This will improve the screening timeserve as an alternative for patients in therapeutic try.

The TSRI biomedicalepidemic prevention sensor chip platform uses multi-functional integrated design, with advanced sensorchip design technologies integrating with AI systems, to achieve the goal of diversified epidemic prevention. The platform is open for R&D teams from industryuniversities to develop genetic engineering modification of specific virus typesestablish DNA identification technology, as well as to accelerate development cycle for emerging virus detectorsshorten the virus detection time.

This product provides "Microfluidic sensing system for on-site rapid detection of early-stage acute kidney injury" for the hospital＇s intensive care unit, operating room, nephrology departmentcardiology department. It can replace the lengthycumbersome traditional instrumentationeasily access at the point of care.

The present sperm sorting chip utilities the upstream swim characteristic of sperms in appropriate fluid velocity to achieve up to 80 high motility sperm yield for infertile males in just 40 minutes

Within 10 years, Taiwan will become a super senior society with the proportions in silver hairs of more than 20. Thus, a high-throughputsmart platform with bio-physiology-marker panels is developed for PD progression by combining the bio-medicalphysical sensors, SPRsmart circuit design, leading to a new UPDRS for a more accurateearly diagnosis of a physician.

Assisted by in-house AI deep compression toolchain (ezLabel, ezModel, ezQUANT, ezHybrid-M), the proposed technology supports automatic AI model designoptimization with the integrated performance of 120x model size reduction70x power reduction in 2D CNN model,develops a world-first 1/2/4/8-bit CNN model realized by the developed high efficiency Hybrid fixed point CNN NPU (Hybrid-NPU), which has been verified in Xilinx ZCU102 FPGAachieves the performance up to 2.5 TOPS(8-b)/ 20TOPS(1-b)@28nm technology running at 550MHz4TOPS/W energy efficiency.

Superconducting qubit is the basic structure for constructing the quantum computer in the current approach. The superconducting-quantum-bit simulation chips (SC-qubit chip) that consist of 1-4 qubits are manufactured locally by domestic researchers. The SC-qubit chip is designed for simulation of artificial atoms, their mutual interactionstheir interactions with microwavesvacuum fluctuations.

This research presents a genetic variant discovery SoC for analyzing Next-generation sequencing data which is embedded with the processorconnected with some peripherals. With hardware-optimized algorithm sBWT, we greatly speed up the process of short reads mapping by k-ordered FM-indexsuffix grouping. After short reads mapping, we utilized de bruijn graph for sequence assembly to rebuild haplotypes,built haplotypes are compared to the reference genome to detect genome variations. The detected variations are written to files for further clinical diagnosisresearch analysis.

Due to the recent outbreak of COVID-19ongoing mutants, we developed a coronavirus variant protein microarray that includes all the current spike mutationsthe wild-type viral antigensapplied in detecting immune responsesdrug specificities. We filed the patientspublished our findings in the Analytical Chemistry. Besides massive production of the coronavirus protein microarray, we also collaborated with a scanner company, developed artificial intelligence software,collaborated with suppliers. We are welcome any sort of collaboration.

The major cost of conventional RFID tags comes from a microchip. To reduce the start-up cost, we develop a chipless RFID system that eliminates the use of the chip. This research organize the real-world issues of chipless RFID into four subjects, including the design of chipless tags, chipless RFID readers, reader signal processing,wireless propagation channel. We successfully integrate the four topics, developing a calibration-free, orientation-insensitive,high-capacity chipless RFID system with multi-tag detection capability.

Based on the mass production technique to fabricate 2D materials developed by our group, efficient gas sensors against NOx with sensitivity of 100 ppb are successfully demonstrated. In comparison to international competitors, our products exhibit superior sensitivityselectivity. Furthermore, the technique would be extended to other 2D materials to fabricate various gas sensors against multiple target gases. The integration with internet of things would then open new feasibilities for early monitoring in environmental pollutionhuman safety.

We are proposing a pipeline including de novo genome assemblywhole genome SNP array design to improve the practice in precision medicineprecision agriculture. We design GABOLA, a de novo genome assembly system, combining advantages in leading sequencing platform, to construct completeaccurate individual genomes. GABOLA can resolve large structural variants, fills the gap in human reference genome,avoid the bias from reference genome. We combine the knowledge of population geneticsfunctional information to design whole genome SNP array to aid future genomic study.

A microfluidic diffraction device is developed for determination of CTC/bacteria from human whole blood with a home-constructed laser beam system. We design the optical structuretransfer the structure to transparent plastic substrate. The plastic diffraction die is modified with antibodies of the target to combine a fluidic system as a microfluidic diffraction chip. When human whole blood with CTCs/bacteria flows through the chip, the number of cells/bacteria can be obtained directly with label-free. The devices has been applied in clinical diagnosis of oesophagealendometrial cancer.

Cancer is the first leading cause of death in Taiwan. Targeted therapy allows the cancer cells to be specifically targeted, reduces the side effects,achieves the purpose of precision cancer treatment. This report contains two invention technologies which combined early & specific diagnosis of a specific Aurora-A mRNA isoform in cancers (the companion diagnosis)the treated with a selective locked nucleic acid (LNA)-modified novel double-stranded short interfering nucleic acid (siRNA) to inhibit the translation of this Aurora-A mRNA isoform (targeted therapy) in cancers.

This project designs a biomedical theranostic chip for neural disorders. It can not only function as an implantable device for treating the Parkinson＇s disease, depression, dementia, but also monitor physiological signals in wearable devices. For the development of medical device, the NeuLive system based on the microchip can accelerate the pre-clinical data collectionverification.

Devices with physical flexibilitystretchability have attracted a great deal of interest for use in wearable electronic technologylarge-area electronics, including displays, energy harvesters, energy storage devices, distributed sensor networks,Internet of Things applications. The present invention relates to methods for growingtransferring single-crystal III-nitride nanorodstwo dimensional transition metal dichalcogenides (2D TMDs) nanostructures,devices having the transferred nanostructures for flexible device, microLED,3DIC fabrications.

Given its own researchdevelopment advantages of biomedical core facilities, as well as testingverification capabilities, Taiwan Instrument Research Institute (TIRI) provides a one-stop service for medical device R&D teams from prototype counseling to product testingverification. Based on the medical device accelerator platform, TIRI assisted the medical device R&D teams to accelerate the commercialization of their R&D results. Through the Medical Device Service Platform, TIRI helps manufacturers join in combatting the pandemic.

A phosphate-sensing chip was constructed by a copper phosphate-deposited electrode. The modification of ionic liquidplasticizer can improve the selectivity of phosphate anionsreduce the interference of sulfate, nitratechloride anions. The sensing chip equipped with a portable electrochemical device can directly detect the phosphate concentration of solution extracted from soil samples in ten minutes by using amperometry. The sensing chip promises the feasibility of detecting the phosphate concentration without expensive instrumentlabor-intensively chemical colorimetry.

Here, we introduce an electricity-free centrifuge platform based on a manual centrifuge. The provided centrifugal force is sufficient to produce a plasma purity of 99 separated in as little as 2−3 min. We then performed an immunoassay on a paper devicethe results were observed by a portable reader. As a result, the detection limit of the C-Reactive Protein is 1 ng/mL, with a total turnaround time of 7 min.

The objective of this project is to develop a portablewireless urine detection systemplatform for prevention of cardiovascular disease. The main idea is to develop a system-on-chip, a microelectrodemicrochannel chip to detect biomarkers concentrations in urine. And then, it will be wirelessly transmitted to a smart application platform to evaluate user’s cardiovascular status.

A high power converter application built with GaN HEMT was presented. The technical aspects are developed from 6-inch wafers to converter applications, covering the optimization of 6-inch GaN epitaxial layers. The processdevice model of the 6-inch GaN E/D-mode component was established. Low-side GaN HEMT logic gates ( 2MHz) for integrated circuit were designed. Finally, The high-frequency LLC resonant converter is completed.

Monitoring PCDM-specific biomarkers, galectin-3S100A9, to serve as a risk assessment of pancreatic cancer on new-onset diabetes patients for early detection of PC.

Our technology combines optimized semiconductor manufacturing technique with unique biomediator preparation to achieve the first reliable POC biosensing platform. Sensors developed according to this method possess reproducibility, accuracy,stability that meet POC. Our sensors are portable, require low sample volume, do not require sample processing,are extremely suitable for use in POC settings. They can also be integrated into IoT systems to aide in rapid decision making,can be mass produced. Overall, we are the first to achieve accessible, reliable detection at the POC.

"Introduce dielectric-fuse breakdown OTP (dFuse-OTP) technology: a.) dFuse is a newly discovered OTP mechanism which is totally different from the conventional mechanisms of anti-fuse, eFuse,charge-storage b.) IPs of dFuse OTPs have been protected globally c.) dFuse OTPs are totally integratedcompatible in the standard CMOS technologies without any additional masks d.) small layout celllow cost e.) dFuse OTPs have been at the phase of trial production in the first two big Taiwanese foundries."

The location of controlled-grain Si island is determined by the pattern of “cooling holes”. The grain size is determined by the distance between “holes” due to lateral grain growth using pulse laser crystallization. This predictability allows the transistorscircuits to stay away from the grain boundaries for monolithic

Low-power deep learning accelerator integrates neural network design / training, model compressionaccelerator design. It uses a small amount of computationmemory footprint to realize high performance on the edge device. The image semantic segmentation technology can reach 80 frames per second (resolution:1024*2048) to meet real-time requirements for autonomous driving.