We provide antibody-based solutions to human diseases with short development course at low cost, are based on the phage-displayed GH (Generic Human) synthetic antibody libraries designedconstructed with enabling approaches, leading to the throughput capacities to uplift the innovativenessproductivity in developing antibody therapeuticsdiagnostics. In conjunction with the core technologies, antibody bioinformatics capable of extracting knowledge from big data of human antibody repertoires is used to elucidate human antibody responsesto assist antibody library design.

In order to improve the disease-selectivitysafety of antibody drugs, we use the autologous hinge as an antibody lockuse protease substrate peptide as linker to generate pro-antibody. Only in the disease area, the overexpressed protease will restore the function of the antibody. The antibody lock can improve the safety of antibodiesthe quality of patient medications. This technology has global patents (granted in 15 countries)technology transfer experience. We believed that the universal antibody lock will bring a revolutionary breakthrough in antibody drugs.

(1) High flux mode for integrated measurements of SAXS/WAXS/UV-Vis-absorption/Refractive-index/Multi-angle-light-scattering (MALS) with an online high-performance liquid chromatography (HPLC) instrument, suitable for exploring biomacromolecular solution structures of a wide length scale and structural kinetics down to microsecond time scale. (2) Ultra SAXS (USAXS) mode for resolving hierarchical structures of bio-machinery assembly up to a few um length scale. (3) Anomalous SAXS mode for metal or mineral distributions (including calcium) in bio organelle or drug carriers. (4) Microbeam SAXS/WAXS mode for structural mapping of the textures or specific infected cells in natural/synthetic bio-tissues, organelles, or biomaterials.

1.High flux mode for integrated measurements of SAXS/WAXS/UV-Vis-absorption/Refractive-index/Multi-angle-light-scattering (MALS) with an online high-performance liquid chromatography (HPLC) instrument, suitable for exploring biomacromolecular solution structures of a wide length scalestructural kinetics down to microsecond time scale. 2.Ultra SAXS (USAXS) mode for resolving hierarchical structures of bio-machinery assembly up to a few m length scale. 3.Anomalous SAXS mode for metalmineral distributions (including calcium) in bio organelledrug carriers.