We designed a cascade spiral microfluidic device (i-Finity®)continuously isolated the unlabeled cancer cells from blood samples without lysing processes. The results showed that the i-Finity® device excluded a high percentage of RBCs in the first stagerecollected the cancer cells in the second stage. The i-Finity® device can efficiently enrich the cancer cells more than 1000 times in 10 minutes, which substantially curtailed sample preparation timeimproved the accuracy of diagnosis.

Lung-on-minilab is designed as a tool for personalized healthcarewill contribute in precision medicine. Here, the tumor microenvironment was reconstituted using liquid dielectrophoresisarranged as lung tissue. The size of pattern can be customized as stages of cancer. Additionally, this chip was equipped a gradient microfluidic channel which enabled testing combination of medications. This is the first device where chemotherapyimmunotherapy medications can be tested together. This will improve the screening timeserve as an alternative for patients in therapeutic try.