In this technology, a series of potent MOR/NOP agonists has been developed, which demonstrated potent antinociception in tail flick and cancer pain mouse models with fewer side-effects in respiratory suppression, heart rate decreasing, and constipation models than morphine.

In order to improve the disease-selectivitysafety of antibody drugs, we use the autologous hinge as an antibody lockuse protease substrate peptide as linker to generate pro-antibody. Only in the disease area, the overexpressed protease will restore the function of the antibody. The antibody lock can improve the safety of antibodiesthe quality of patient medications. This technology has global patents (granted in 15 countries)technology transfer experience. We believed that the universal antibody lock will bring a revolutionary breakthrough in antibody drugs.

This technology is mainly solved the side effects of anti-obesity drug, including soft stoolsoily stools,regulate oil absorptionmetabolism as an additive in food. During the experiment, the curing phenomenon of MSNs/oiloily stool reduction in animal were observed. In conclusion, MSNs can effectively reduce the side effects of Orlistatelevating life quality.