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    • Low-dose nanoscale biomimetic cell structure – Next-generation platform technology for advanced precision immunotherapy

      Precision Health Ecosystem FutureTech Low-dose nanoscale biomimetic cell structure – Next-generation platform technology for advanced precision immunotherapy

      We developed a biomimetic triple-antibody-immobilized magnetic fucoidan nanomedicine as a multifunctional artificial antigen presenting cell, which possessed the ability to not only inhibit immune checkpoint but activate tumor infiltrated T cells. of Bridging sites with tunable density on the nanoplatform was designed, allowing the antibodies to be well-distributed on the surface for mimicking immune cells. In contrast to the complex cell expansion process using microbeads in adaptive cell therapy, the nanoplatform can be i.v. administrated to cut the course of therapy from several weeks to days. With the development of the platform technology, an artificial immune system family can be built to pave the way for personalized immunotherapy.
    • A Manual CentrifugePaper Devices for Point-of-Care Diagnosis

      Precision Health Ecosystem FutureTech A Manual CentrifugePaper Devices for Point-of-Care Diagnosis

      Here, we introduce an electricity-free centrifuge platform based on a manual centrifuge. The provided centrifugal force is sufficient to produce a plasma purity of 99 separated in as little as 2−3 min. We then performed an immunoassay on a paper devicethe results were observed by a portable reader. As a result, the detection limit of the C-Reactive Protein is 1 ng/mL, with a total turnaround time of 7 min.
    • Infectious Disease Diagnosis and Water Quality Monitoring Using Nanomaterials Immobilized Paper and a Flow Controllable Microfluidic Device

      Precision Health Ecosystem FutureTech Infectious Disease Diagnosis and Water Quality Monitoring Using Nanomaterials Immobilized Paper and a Flow Controllable Microfluidic Device

      Here we present a portable microfluidic device that can perform immunoassay for infectious disease diagnosis or detect heavy metal ions in water samples. The device is composed of two major components: nanomaterials modified paper-based detection platform and semi-automated flow manipulator. A reusable 3D-printed device is used to hold a disposable detection pad that modified with functional nanomaterials for water quality monitoring or antibodies for disease diagnosis. Besides, the use of spring-containing 3D-printed syringes manipulates a large-volume sample without manual actuation. Meanwhile, by controlling the flow rate via the linked flow regulator at the syringe outlet, solutions can react stably with the paper platform, which provides detection and pre-concentration effects.
    • 攜帶式傳染病分子診斷系統

      Precision Health Ecosystem FutureTech 攜帶式傳染病分子診斷系統

      "We present here a portable device with isothermally mediated loop amplification (LAMP) for the diagnosis of infectious diseases. The main components included (1) roller conveyor, (2) hotplate,(3) temperaturemotion control panels. After mixing all the solutions by rollingsqueezing the sealed compartments, the LAMP strip was heated for 30 min for amplification. Finally, fluorescence results can be read with the naked eyeon a smartphone under the UV lamp. The 700g device is powered by a portable charger, making it easier to detect pathogens in resource-limited environments."
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