Blood

These stimuli-switchable nanoparticles coated with the cleavable outer polymer coatingmultifunctional peptides may afford a new platform for anticancer drugmiR. These nanoparticles possess characteristics of environmental response, active targeting,gene/chemo combinatorial therapeutics, thus providing spatiotemporal control of posttranｓｃｒｉｐｔional gene regulation, smart nuclear/mitochondrial localization,simultaneous inhibition of multiple progression pathways of tumor cells for enhancing antitumor efficacysafety of cancer therapy.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

The technology is video-based blood pressure monitoring which will help people know the continuous BP status in real time. Also, the contactless measurement can make a daily health record. We have conducted clinical trials in hospitalsestablished a large database to optimize AI solution. The system joins the physicians＇ specialty to analyze the users＇ health status with AI,takes care of human life with technology.

EPICAn is a novel technique that uses liquid biopsy for epigenetic analysis. Using methylation-specific PCR method to analyze specific gene methylation of cell-free DNA in plasma for early detection of breast cancer. The advantages of this technology are 1. High accuracy 2. Low false positive rate 3. Low-invasive 4. less limitation 5. Available for routine continuous detection 6. Monitoring cancer changes 7. Aided diagnosis 8. Automated process 9. Easy-to-operate 10. Rapid analysis. It is expected that EPICAn technique can increase the accuracy of early detection of breast canceraid clinicians diagnosis.

We constructed a model to differentiate different neurodegenerative diseases by using blood-based biomarkers. Linear Discriminant Analysis (LDA) was used to reduce dimensionsMICE (Multivariate Imputation by Chained Equations) was used for missing value treatmentchoose CART model to predict missing value imputation. This machine learning model would be used for early dectection of neurodegenerative diseases.

The autologous platelet concentration filter mainly filters the blood platelets to selectively capture the platelets in the blood,re-releases the platelets captured by the membrane through the secondary extraction method. The main principle comes from the control of membrane holesmembrane. The surface modification technology, multi-layer laminated membranethe control of the extraction design make it possible to quickly obtain autologous platelets concentrated.

The technology utilizes image continuity and contactless monitoring of blood pressure and respiration state to help patients avoid wearable pressure when detecting sleep apnea and reduce the complexity of detection. The system can help users to easily detect sleep status in their lives, contactlessly measure and make daily health records, as the real-time management monitoring of daily homecare. This technology conducts IRB clinical trials, establishes a large database, joins physician professions, and optimizes AI solutions.

A flexible PPG sensor patch for measuring pulsations of blood vessels estimating ambulatory blood pressure monitoring (ABPM). The measured quality PPG signals are analyzed to estimate blood pressure (BP), heart rate (HR), blood oxygen (SpO2)atrial fibrillation (A-Fib)avoid motion artifacts. In this way, with subject’s physiological condition apprehended accurately.

This invention is to apply PS1 to treatreverse T2D. The invention can be developed into small-molecule drugs. Those are first-in-class drugs for T2D because its novel anti-diabetic mode of action.

A microfluidic diffraction device is developed for determination of CTC/bacteria from human whole blood with a home-constructed laser beam system. We design the optical structuretransfer the structure to transparent plastic substrate. The plastic diffraction die is modified with antibodies of the target to combine a fluidic system as a microfluidic diffraction chip. When human whole blood with CTCs/bacteria flows through the chip, the number of cells/bacteria can be obtained directly with label-free. The devices has been applied in clinical diagnosis of oesophagealendometrial cancer.

Our system is achieved by integrating diffractiondeep learning methods, which allows high-throughput lensless imaging system to display wide rangehigh-resolution images. In addition, the developed extraction chipsprototype were verified to accurately detect the numberproportion of blood cells under low blood demand. Our system shows great potential in point-of-care blood cells monitoring for cancer patients that could reduce infection riskmortality rate, increase efficacy of chemotherapysupport precision medicine.

Two COVID-19 animal models, including humanized Ace2 micehuman peripheral blood lymphocyte transplanted mice, are used to mimic COVID-19 infection, immune responsecytokine release syndrome in human. The immune analytical platform can further outline the immune cell, cytokinebiomarker response pattern after viral infection. The COVID-19 humanized animal modelthe immune analytical platform will support COVID-19 related researchfacilitate new drugnew therapy validation.

Here, we introduce an electricity-free centrifuge platform based on a manual centrifuge. The provided centrifugal force is sufficient to produce a plasma purity of 99 separated in as little as 2−3 min. We then performed an immunoassay on a paper devicethe results were observed by a portable reader. As a result, the detection limit of the C-Reactive Protein is 1 ng/mL, with a total turnaround time of 7 min.

This product provides "Microfluidic sensing system for on-site rapid detection of early-stage acute kidney injury" for the hospital＇s intensive care unit, operating room, nephrology departmentcardiology department. It can replace the lengthycumbersome traditional instrumentationeasily access at the point of care.

Due to the inconvenience of the conventional drip frame, this invention applies fuzzy control logican inverted-pendulum system to build up a reliable system, which facilitates patient mobilityensure safety with compensating the inclination angle of the piggyback intravenous drip frame based on the motion information of the patient.

To train neurosurgery internsincrease their confidencesurgical skills, we employed 3D printing, mold design,casting technology to develop medical simulators. The simulators allow students to adjust the angle of the head based on the location of the angioma (brain tumor), perform a craniotomy, move the soft tissue of the brain aside using forceps, locate the angioma (brain tumor),clip the angioma (remove the brain tumor) using medical instruments,complete the entire training while artificial blood is flowing through the simulator.

We developedoptimized a FRET-based genetically-encoded biosensor Met-lead with high sensitivity 10nM (0.2μg/dL, 2ppb) to fit the related regulations: the safety value of blood lead level for children 3μg/dLWHO-permitted level for tap water 10ppb. We further built a portable smart-phone device to measure Pb on-site. The practical applications of portable Met-lead can fulfill the needs from blood/urine Pb detection to drinking water/environmental irrigation water Pb monitoring, it will also help to build up a warning system to prevent further contamination from heavy metal Pb.

The developed multi-functional bio-sensor chip has the advantages of excellent detection performance, wide application,low mass production. At present, we have already cooperated with upstreamdownstream manufacturers for mass production of the multifunctional bio-sensor chips. At the same time, cooperate with the instrument manufacturer to develop a simple portable electrochemical detect

Integrated Taiwan＇s superior industries such as semiconductor manufacturing processes, precision micro-molding, hot embossing,chip packaging to develop Pt/Au nano-alloy electrodes with applications in neutral non-enzymatic glucose biosensorsneutral non-enzymatic glucose biofuel cell. This novel Pt/Au nano-alloy electrode possesses advantages of technology foresight, good detection perfor