不孕症

These stimuli-switchable nanoparticles coated with the cleavable outer polymer coatingmultifunctional peptides may afford a new platform for anticancer drugmiR. These nanoparticles possess characteristics of environmental response, active targeting,gene/chemo combinatorial therapeutics, thus providing spatiotemporal control of posttranｓｃｒｉｐｔional gene regulation, smart nuclear/mitochondrial localization,simultaneous inhibition of multiple progression pathways of tumor cells for enhancing antitumor efficacysafety of cancer therapy.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

We developed a new type of microfluidic chip with utilizing the characteristic of sperm anadromous instinct for high-throughput sperm separation. The process can be finished in 10 min, which is 10 times faster than the conventional design. Experiment reveals that the qualified sperm motility was raised up from 30 to 99linearity (LIN) up from 0.2 to 0.85 via sorting by our microfluidic chip.

Infertility is a serious globe issue, especially in the developed countries, over 20%infertile male has sperm problems, that include instance immotile, abnormal morphology and low sperm quantity. Therefore, how to isolate high quality sperm for clinical use is extremely required. Up to date, activity sperm sorting is usually using Swiming-up and Density gradient centrifugation approaches. Unfortunately, both methods are detrimental to the sperm viability and elicits production of reactive oxygen species. Separation sperm by microfluidics has been put emphasis on and studied; however, it faced some challenge such as low throughput and an unacceptable recover rate.