非線性光學

These stimuli-switchable nanoparticles coated with the cleavable outer polymer coatingmultifunctional peptides may afford a new platform for anticancer drugmiR. These nanoparticles possess characteristics of environmental response, active targeting,gene/chemo combinatorial therapeutics, thus providing spatiotemporal control of posttranｓｃｒｉｐｔional gene regulation, smart nuclear/mitochondrial localization,simultaneous inhibition of multiple progression pathways of tumor cells for enhancing antitumor efficacysafety of cancer therapy.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

We have successfully developed a multiphoton-induced hyperspectral microscopy based on a 1064 nm femtosecond excitation source. Nonlinear excitation by the laser localized to the focal point allows efficient non-descanned detection (NDD) while achieving optically sectioned imaging. The use of 1064 nm laser excitation increases the imaging depth while minimizing sample damage. The system combines the advantages of NDD for 3D imagingrich spectral information through confocal hyperspectral imaging, leading to potential applications in the emerging material R&Dbiomedical research.

This technique uses multimodal nonlinear optical microscopy with the image contrast of second harmonic generation (SHG)coherent anti-Stokes Raman scattering (CARS). By analyzing the nonlinear signals on images, it can be used to characterizequantify the structural variation in the collagen scaffolds processed with different crosslinking methods. The correlation between signalsmechanical properties can then be derived. Additionally, comparative analysis of these two signals can be used to monitor the structural (triple-helix) change of collagen molecules during the crosslinking processes.