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These stimuli-switchable nanoparticles coated with the cleavable outer polymer coatingmultifunctional peptides may afford a new platform for anticancer drugmiR. These nanoparticles possess characteristics of environmental response, active targeting,gene/chemo combinatorial therapeutics, thus providing spatiotemporal control of posttranｓｃｒｉｐｔional gene regulation, smart nuclear/mitochondrial localization,simultaneous inhibition of multiple progression pathways of tumor cells for enhancing antitumor efficacysafety of cancer therapy.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

We originally design a highly efficient NdYVO4/KGW Raman laser at 579.5 nm. The KGW crystal is specially coated to prevent the Stokes wave from propagating through the gain medium so as to minimize the cavity losses. Moreover, we explore a new output coupler with double-sided dichroic coating to exterminate the leakage power of the Stokes wave to lead to a remarkable improvement for the output efficiency. The maximum output power can be up to 10.5W at a pump power of 40W. The conversion efficiency of the diode pump light to yellow laser output can be increased to 26.3.

(1) Image recognition3D positioning of the pest: Modularize the system for testing on the orchard. (2) High efficiency laser pest control scanning system: It was developed to be suitable for windlessbreezy environments. (3) Enhance the economic tracked vehicle for hillside field: Self-developed power designsteering control based on dynamic model,(4) Field UGV control platform: Based on the preciseaccurate positioning in field, when robot operates on the reference path which planned by map, it can do path trackingdynamically obstacle avoiding in real-time.

Laser material recognition technologyintelligent color compensation lighting system, with AUV to realize the function of underwater rust detectionimage color restoration, real-time acquisition of rust information through spectral analysisdisplay of true rust color on the image, so that the algorithm can be accurate Determine the health of the cylinder. The vehicle will establish the health information of the wind turbine to help the inspector make the best maintenance strategymaintain the power generation efficiency of the wind turbine in the best condition.

Based upon Coherent Förster Resonance Energy Transfer, we have successfully demonstrated the first colloid quantum dot laser with two different kinds of quantum dots (donorsacceptors) in the light emitting layer. The donors can resonantly transfer energy into the acceptors,they also act as scattering centers. Through multiple scattering, it can form a coherent closed loop. All the donors can coherentlyresonantly transfer energy into all the acceptorsthe laser action is achieved.

A microfluidic diffraction device is developed for determination of CTC/bacteria from human whole blood with a home-constructed laser beam system. We design the optical structuretransfer the structure to transparent plastic substrate. The plastic diffraction die is modified with antibodies of the target to combine a fluidic system as a microfluidic diffraction chip. When human whole blood with CTCs/bacteria flows through the chip, the number of cells/bacteria can be obtained directly with label-free. The devices has been applied in clinical diagnosis of oesophagealendometrial cancer.

In NSRRC, we set up a superradiant free electron laser in terahertz frequency range by employing an in-house developed laser-driven photocathode radio frequency electron gun system and a technology called radio frequency electron bunch compression. It is currently the terahertz radiation source with the highest peak power in Taiwan. In addition, we also designed an extreme ultraviolet free electron laser test facility that is based on similar technology. These light sources can be applied significantly to research fields such as semiconductors, quantum materials, and biomedicine.

Through combining the cutting-edge technology of TD-ESI/MS to its comprehensive database library of toxicants, a fast-track toxicant analytical platforma set of standard operating procedures are developed that enables the emergency physicians to access correct toxicological information within a short turnaround timerescue the poisoned patients based on accurate laboratory data.

Photonic_Workshop@CCMS.NTU has successfully developed a motorized micro-mapping system to explore and navigate samples. This system is able to acquire high resolution images to produce a sample map automatically. This map is also synchronized with the coordinates of motorized stages. This achievement allows users to explore and position their hotspots from the map, and precisely deploy the hotspot to the central field of view by motorized stages. In addition, this mapping system can combine with a laser scanning confocal spectral microscope (LSCSM) to acquire sample spectral mapping. Our result has shown the capability to improve the efficiency of hotspot positioning and data acquisition process.

Prof. Chen＇s research team at IPT NTHU achieved a breakthrough to build table-top coherent EUV light source. This new accessiblereliable EUV light source makes a lot of the first possibilities, enabling the dynamics of chemical reactions, nano-materialsbio-molecular systems to be studied with unprecedented temporalspatial resolution, e.g. coherent 13.5nm EUV light source for nm-scale defect inspection.

ULF Raman spectroscopy utilizes novel VHG filters to spectrally clean up the laser line before ULF Raman spectroscopy is measured with a single grating spectrometer in conjunction with CCD camera. The availabilityaccessibility of UFL Raman spectroscopy opens new opportunity to reveal key information such as intermolecular structure characterization, pharmaceutical polymorph identification,material phaseinterfacial structure determination.

Nanopharmaterial is a term by combining pharmaceuticalmaterial via nanotechnology. Here we demonstrate this concept by developing a novel nanopharmaterial, so called 177Lu-Gold nanostar (AuNS). 177Lu is a therapeutic radionuclide emitting moderate-energy beta particles as well as gamma rays for SPECT/CT-based imaging diagnosis. Nanostar can target tumors by enhanced permeability retention (EPR) effectsowns the photothermal therapeutic potent. The core technology is to integrate radionuclidenanomaterial to perform a new radio-nanopharmaterial for tumor target theranostic purpose.

In autonomous driving, LiDAR can clearly distinguish the objectsget the object information such as speeddistance at medium-range (~100 m) for autonomous driving scheme entering Level 3. Therefore, in this study, we combine the reflective optical phased array (OPA) chip1550-nm VCSELs with a photodetector, a ToF chip,a microcontroller to produce an eye-safe, all-solid-state,low cost (less than $100 USD) LiDAR module, which is the world＇s leading LiDAR technologymore cost-effective than the current products for autonomous vehicle market.

Two new kinds of the standard leak elements (SLEs), with a microfluidic channel in diameter of several-micrometerslength of several-hundred-micrometers, have been developed by femtosecond (fs) laser micromachining. A technique based on the conductance modulation method can be used to accurately determine the tiny conductance ( 1×10-6 L s-1) of these SLEs.

The location of controlled-grain Si island is determined by the pattern of “cooling holes”. The grain size is determined by the distance between “holes” due to lateral grain growth using pulse laser crystallization. This predictability allows the transistorscircuits to stay away from the grain boundaries for monolithic

ALTOMS (Altomated Laser TrackingOptogenetic Manipulation System) is a real-time computer vision object recognitionlaser tracker. It uses a missile-like image recognitiontracking technology,uses several lasers to accurately hit the tracked object. The laser itself does not have the function of controlling nerves, but when we express light-sensitive proteins on specific nerve cells, we can stimulateinhibit nerves through lasers of specific wavelengths, which will affect the behavioral outcome.

With the development of photonics, there has been a push towards optoelectronic devices that are flexible, rollable, wearable, user-friendly, and robust to improve human-machine interfaces. To be integrated onto human body, these devices must be biocompatible and be able to withstand mechanical deformation and different bending curvatures. Figure 1 shows the rollable and soft photonic meta-device.

We have successfully developed a multiphoton-induced hyperspectral microscopy based on a 1064 nm femtosecond excitation source. Nonlinear excitation by the laser localized to the focal point allows efficient non-descanned detection (NDD) while achieving optically sectioned imaging. The use of 1064 nm laser excitation increases the imaging depth while minimizing sample damage. The system combines the advantages of NDD for 3D imagingrich spectral information through confocal hyperspectral imaging, leading to potential applications in the emerging material R&Dbiomedical research.

This project is used for advanced driver assistance systems (ADAS)automatic driving. At present, our project will use a more sensitive CMOS single photon detector array to reduce the number of photons required for detection to less than ten, in order to break through the cost barriers of applications of LiDARestablish low-cost, high-performance LiDAR modules.

Our solution is able to noninvasively reconstruct 3D skin microstructuremicroangiography with micrometer-scale resolutions for diagnoses of skin disorders. Moreover, various skin parameters can be quantitatively evaluated from 3D images according to the proposed algorithms, including the thickness of stratum corneum, the thickness of epidermis, water concentration, collagen concentration,skin roughness. The developed technique can be applied to different clinical environments including hospitalscosmetic clinics for diagnosesanalyses of skin.

In this study, the embedded LiDARAI recognition of smart headlight for autonomous driving is demonstrated. At driving process, the vehicle can provide artificial intelligence to identify the type, distancespeed of the object to be measured based on the fusion data of the LiDAR point cloudoptical image of the environment,then feedback to the headlight control system. Finally, this smart headlight would perform the suitable lighting mode during the daynightfit the automotive lamp safety regulationsstandards (ECE R112SAE J3069).

Constructing a functional connectome and its computational model is a crucial step toward understanding the mechanisms of brain functions. To achieve this goal, we developed two correlated technologies: (1) An all-optical physiology (AOP) that is capable of millisecond volumetric imaging and accurate stimulation in living animal brains. This system allows us to establish functional connectome and neural coding with a single-cell resolution. (2) A cellular-level spiking neural circuit simulation system that is capable of tuning itself based on the input data from the AOP system. We have demonstrated our technologies in the Drosophila late visual system and will apply them in the brains of larger species such as mice. Our technologies will greatly enhance knowledge of brain operation.

Our portable mass spectrometer is the first miniature high resolution high mass range mass spectrometer in the world, breaking through the bottle neck of conventional instruments to offer competitive performance to the commercial counterparts,performs even better in high mass range. This instrument has been successfully applied to microbial identificationhelped with samples which are difficult to detect in conventional instruments, exhibiting the advantage of precision analysis.