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These stimuli-switchable nanoparticles coated with the cleavable outer polymer coatingmultifunctional peptides may afford a new platform for anticancer drugmiR. These nanoparticles possess characteristics of environmental response, active targeting,gene/chemo combinatorial therapeutics, thus providing spatiotemporal control of posttranｓｃｒｉｐｔional gene regulation, smart nuclear/mitochondrial localization,simultaneous inhibition of multiple progression pathways of tumor cells for enhancing antitumor efficacysafety of cancer therapy.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

The technology designs a modular friction stir welding tool holder. This welding tool holder integrates a variety of functions, including constant pressure welding, temperature monitoring, removable FSW tool design,can be clamped to an existing CNCmachine. The advantage is that it can realize the function of automatic exchange for friction stir weldingCNC milling in one machine. Breaking through the previous friction stir welding, you need to buy a friction stir welding machine, which is expensive to obtain.

1. Demonstrate Virtual Manufacturing/AR/VR technology, integrate product designprocess planning processes (simultaneous engineering). 2. 3D printing design system: Utillized Rhinos built-in calculation editor Grasshopperinfinite element method to generate complex lattice microstructures. The lattices model could directly transfer to all types additive manufacturing machine to fabricate the designs, allowing for rapid prototypinglattices shapes iteration.