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These stimuli-switchable nanoparticles coated with the cleavable outer polymer coatingmultifunctional peptides may afford a new platform for anticancer drugmiR. These nanoparticles possess characteristics of environmental response, active targeting,gene/chemo combinatorial therapeutics, thus providing spatiotemporal control of posttranｓｃｒｉｐｔional gene regulation, smart nuclear/mitochondrial localization,simultaneous inhibition of multiple progression pathways of tumor cells for enhancing antitumor efficacysafety of cancer therapy.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

We constructed a model to differentiate different neurodegenerative diseases by using blood-based biomarkers. Linear Discriminant Analysis (LDA) was used to reduce dimensionsMICE (Multivariate Imputation by Chained Equations) was used for missing value treatmentchoose CART model to predict missing value imputation. This machine learning model would be used for early dectection of neurodegenerative diseases.

Our system is achieved by integrating diffractiondeep learning methods, which allows high-throughput lensless imaging system to display wide rangehigh-resolution images. In addition, the developed extraction chipsprototype were verified to accurately detect the numberproportion of blood cells under low blood demand. Our system shows great potential in point-of-care blood cells monitoring for cancer patients that could reduce infection riskmortality rate, increase efficacy of chemotherapysupport precision medicine.

EPICAn is a novel technique that uses liquid biopsy for epigenetic analysis. Using methylation-specific PCR method to analyze specific gene methylation of cell-free DNA in plasma for early detection of breast cancer. The advantages of this technology are 1. High accuracy 2. Low false positive rate 3. Low-invasive 4. less limitation 5. Available for routine continuous detection 6. Monitoring cancer changes 7. Aided diagnosis 8. Automated process 9. Easy-to-operate 10. Rapid analysis. It is expected that EPICAn technique can increase the accuracy of early detection of breast canceraid clinicians diagnosis.

The autologous platelet concentration filter mainly filters the blood platelets to selectively capture the platelets in the blood,re-releases the platelets captured by the membrane through the secondary extraction method. The main principle comes from the control of membrane holesmembrane. The surface modification technology, multi-layer laminated membranethe control of the extraction design make it possible to quickly obtain autologous platelets concentrated.

Two COVID-19 animal models, including humanized Ace2 micehuman peripheral blood lymphocyte transplanted mice, are used to mimic COVID-19 infection, immune responsecytokine release syndrome in human. The immune analytical platform can further outline the immune cell, cytokinebiomarker response pattern after viral infection. The COVID-19 humanized animal modelthe immune analytical platform will support COVID-19 related researchfacilitate new drugnew therapy validation.

Here, we introduce an electricity-free centrifuge platform based on a manual centrifuge. The provided centrifugal force is sufficient to produce a plasma purity of 99 separated in as little as 2−3 min. We then performed an immunoassay on a paper devicethe results were observed by a portable reader. As a result, the detection limit of the C-Reactive Protein is 1 ng/mL, with a total turnaround time of 7 min.

This product provides "Microfluidic sensing system for on-site rapid detection of early-stage acute kidney injury" for the hospital＇s intensive care unit, operating room, nephrology departmentcardiology department. It can replace the lengthycumbersome traditional instrumentationeasily access at the point of care.

Due to the inconvenience of the conventional drip frame, this invention applies fuzzy control logican inverted-pendulum system to build up a reliable system, which facilitates patient mobilityensure safety with compensating the inclination angle of the piggyback intravenous drip frame based on the motion information of the patient.

The developed multi-functional bio-sensor chip has the advantages of excellent detection performance, wide application,low mass production. At present, we have already cooperated with upstreamdownstream manufacturers for mass production of the multifunctional bio-sensor chips. At the same time, cooperate with the instrument manufacturer to develop a simple portable electrochemical detect