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These stimuli-switchable nanoparticles coated with the cleavable outer polymer coatingmultifunctional peptides may afford a new platform for anticancer drugmiR. These nanoparticles possess characteristics of environmental response, active targeting,gene/chemo combinatorial therapeutics, thus providing spatiotemporal control of posttranｓｃｒｉｐｔional gene regulation, smart nuclear/mitochondrial localization,simultaneous inhibition of multiple progression pathways of tumor cells for enhancing antitumor efficacysafety of cancer therapy.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

This technology is used to reveal the immune profiling of the tumor microenvironment based on multi-color immunohistochemistry staining. Each immune cell type will be probed with different fluorophores,the density, as well as the location of each immune cell type on the tissue slides, will be disclosed using inForm software.

The technology realizes a perovskite nanocrystal-polymer composite material, which has extremely high stability at room temperaturehigh temperature. It can be used for 3D printing, shaped into fluorescent microfilaments,can also be used for white light-emitting diodes. The application of this air-stabile perovskite nanocrystal-polymer composite material in the 3D printing industry, texti

Our research team has developed a short-wave infrared light gold nanoclusters as an intraoperative fluorescent imaging agent, breaking the light emission limit of the previous gold nanoclusters, shifting the light emission position to the infrared spectrum, successfully avoiding the autofluorescence between the tissuesachieve deeper penetration along with instant bio-imaging. This technology has clearerdeeper imaging benefit with the potential to become a clinical medical infrared imaging agent.

In CB-XLCT imaging, when nanophosphors are delivered to tumor tissues,irradiated by X-rays, luminescent light with wavelength range of 500-700 nm will be exciteddetected by optical camera from different directions. After reconstruction, it can provide tumor locations. The micro-CT subsystem also provide X-rays to excite nanoparticles for luminescence tomography.

CRISPR/Cas9 is the powerfulpopular genome editing technology which can recognize target gene by a single guide RNA with the advantages of precision, high efficiency, easy manipulation,low cost to be applied to promote the precision breeding of aquatic organisms. The potentials of genome editing in the precision breeding of ornamental fish are mainly focused on infertility control, alternation of colorshape, growth promotion, sex control, stress tolerance, virus resistance, etc.

We have successfully developed a multiphoton-induced hyperspectral microscopy based on a 1064 nm femtosecond excitation source. Nonlinear excitation by the laser localized to the focal point allows efficient non-descanned detection (NDD) while achieving optically sectioned imaging. The use of 1064 nm laser excitation increases the imaging depth while minimizing sample damage. The system combines the advantages of NDD for 3D imagingrich spectral information through confocal hyperspectral imaging, leading to potential applications in the emerging material R&Dbiomedical research.

In this study, the embedded LiDARAI recognition of smart headlight for autonomous driving is demonstrated. At driving process, the vehicle can provide artificial intelligence to identify the type, distancespeed of the object to be measured based on the fusion data of the LiDAR point cloudoptical image of the environment,then feedback to the headlight control system. Finally, this smart headlight would perform the suitable lighting mode during the daynightfit the automotive lamp safety regulationsstandards (ECE R112SAE J3069).

In this research, we developed two platforms for analyzing mitochondrial stress. One is to use CRISPR/Cas9 editing to mark a variety of mitochondrial proteins in C. elegansmammalian cells for in vivo assessing mitochondrial functions. Another one is to establish a light-induced DNA damage specifically in mitochondria. In the meanwhile, we also developed a method to

We developedoptimized a FRET-based genetically-encoded biosensor Met-lead with high sensitivity 10nM (0.2μg/dL, 2ppb) to fit the related regulations: the safety value of blood lead level for children 3μg/dLWHO-permitted level for tap water 10ppb. We further built a portable smart-phone device to measure Pb on-site. The practical applications of portable Met-lead can fulfill the needs from blood/urine Pb detection to drinking water/environmental irrigation water Pb monitoring, it will also help to build up a warning system to prevent further contamination from heavy metal Pb.

A new emission model of organic light-emitting diode (OLED) based on triplet-triplet annihilation upconversion (TTAUC) with a high intrinsic upconversion efficiency (86.1) by using tris-(8-hydroxyquinoline)aluminum (Alq3)9,10-Bis(2-naphthyl)anthracene (ADN) as green sensitizerblue emitter, respectively. This structure improved the device efficiencyoperation lifetime compared to the conventional TTA-OLEDs. A record-high efficiency of 15.4EQEa 1.5x lifetime performance comparing to the commercial blue OLED are obtained by utilizing the TTAUC mechanism.