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These stimuli-switchable nanoparticles coated with the cleavable outer polymer coatingmultifunctional peptides may afford a new platform for anticancer drugmiR. These nanoparticles possess characteristics of environmental response, active targeting,gene/chemo combinatorial therapeutics, thus providing spatiotemporal control of posttranｓｃｒｉｐｔional gene regulation, smart nuclear/mitochondrial localization,simultaneous inhibition of multiple progression pathways of tumor cells for enhancing antitumor efficacysafety of cancer therapy.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

X-ray diffraction technology is used to analyze the drug efflux pump, ST50, form S. Typhi. The drug efflux mechanism for multiple drug resistant (MDR) S. Typhithe potential location for antigen of market-based typhoid detection reagent are understood through this ST50 structure. It could help develop the more effective typhoid detection reagentthe new antibiotics against MDR S. Typhi.

Our studies showed the endophyte Burkholderia 869T2 help banana to stand against the Panama diseaseimprove growths of pumpkin, cabbage,other crops. The 869T2 helps plants cope with salinity stresscan decrease dioxin accumulations in plants. The specific metabolite PQQ of 869T2 benefits host plant growths. The beneficial endophytethe metabolite can be developed as an protective endophytic agent.

A method of enhancing a mammalian immune response to a virus is disclosed. The method comprises administering a composition comprising an effective amount of epinecidin (Epi)-1the virus to a mammal, wherein the virus has envelope proteinis infectious to the mammal. In this technique, Epi-1Japanese encephalitis virus (JEV) were mixedinjected into mice. The mice were infected with JEV 14 days later,all mice survived. This technology has also been verified in the preparation of vaccines for foot-and-mouth disease virusnervous necrosis virus.

A microfluidic diffraction device is developed for determination of CTC/bacteria from human whole blood with a home-constructed laser beam system. We design the optical structuretransfer the structure to transparent plastic substrate. The plastic diffraction die is modified with antibodies of the target to combine a fluidic system as a microfluidic diffraction chip. When human whole blood with CTCs/bacteria flows through the chip, the number of cells/bacteria can be obtained directly with label-free. The devices has been applied in clinical diagnosis of oesophagealendometrial cancer.

High entropy materials were proposed and developed by Professor Jien-Wei Yeh in 1995. He named, defined, and elucidated “High-Entropy Alloys,” as well as established High-Entropy Materials Center to develop critical materials for smart machine, green technology, biomedical technology, and national defense. Alloys with high strength, corrosion resistance, and anti-bacterial capability are also developed for manufacturing knives, door handles, handrails, etc. to prevent infection during the post-epidemic era.

We provide antibody-based solutions to human diseases with short development course at low cost, are based on the phage-displayed GH (Generic Human) synthetic antibody libraries designedconstructed with enabling approaches, leading to the throughput capacities to uplift the innovativenessproductivity in developing antibody therapeuticsdiagnostics. In conjunction with the core technologies, antibody bioinformatics capable of extracting knowledge from big data of human antibody repertoires is used to elucidate human antibody responsesto assist antibody library design.

We first reported that Bidens pilosa (BP), an ediblemedicinal plant, suppress coccidiosisgut bacterial infection as evidenced by increased survival rate, better performance, gut pathologymicrobiota in chickens. In addition, combining with probiotics with anti-pathogenic bacteria activityorganic acids synthesis are used as novel natural growth promoters to replace antibiotic growth promoters.

The "Herbmedotcin" technology platform is a major breakthrough in the several thousand years history of herbal medicine knowledge. Use patented technology to find potential natural functional molecules, with appropriate additivesoptimal processing conditions, to achieve a significant increase in their efficacy. This technology is also known as "molecular herbology". They h

The innovative microbial wastewater treatment technology of our team can effectively reduce the COD, BOD, total nitrogen and total phosphorus in livestock wastewater to the emission standards in a short period of time, and the generated microorganisms can be developed for feed additives and organic fertilizers. In terms of industrial wastewater, this technology can also effectively clean petrochemical, ammonia nitrogen and heavy metal wastewater by degrading COD and ammonia nitrogen even adsorbing heavy metals, showing the excellent treatment performances.

Chloroethene is carcinogenic which is extremely harmful to the human. Currently, the effect of bioremediation of chloroethene is efficientit is also friendly to the environment. However, dichloroethenevinyl chloride are the most products that will be accumulated in the environment after dechlorination. Our team isolate the first native Dehalococcoides in Taiwanalso develop a novel dechlorination bio-gel bioremediation technology with silica bio-gel column. Our immobilized system is ａ novel an efficient method to remediate chloroethene into ethene, a non-toxic compound.

Chronic wound infection is a leading cause of mortality in injured patients worldwide. At present, available systemic antibiotic treatments have an insufficient tissue penetration ability and allow the development of antibiotic-resistant pathogens. The identification of therapeutic agents with wound healing and antimicrobial functions is necessary to heal the wound and cure infections. Our report shows that the antimicrobial peptide (AMP) Epinecidin-1 (Epi-1) efficiently heals MRSA-infected heat burn injuries and provides protection from infection in mouse and pig model. Our results demonstrate that the biomaterial Epi-1 heals wounds through increasing epithelial cell proliferation, vascularization, and the formation of collagen and controls MRSA infection-mediated sepsis in pigs.

By integration of professions including phytopathology, pesticides analysis, aquaticlivestock management, microbial fermentation, epidemiology,artificial intelligence, our interdisciplinary team jointly have developed microbial products for multi-industry applications including crop health care, circular agriculture, livestockaquaculture. The intelligent monitoring modelsmanagement technology for evaluating the efficacy of microbial products are implemented to provide key time pointdecision support for microbial products application,in turns to enhance the application efficacy. The developed microbial agentstechnology would greatly reduce the use of chemical pesticidesantibioticsenhance agricultural output valuemarket competitiveness.

In this research, we developed two platforms for analyzing mitochondrial stress. One is to use CRISPR/Cas9 editing to mark a variety of mitochondrial proteins in C. elegansmammalian cells for in vivo assessing mitochondrial functions. Another one is to establish a light-induced DNA damage specifically in mitochondria. In the meanwhile, we also developed a method to