精子

These stimuli-switchable nanoparticles coated with the cleavable outer polymer coatingmultifunctional peptides may afford a new platform for anticancer drugmiR. These nanoparticles possess characteristics of environmental response, active targeting,gene/chemo combinatorial therapeutics, thus providing spatiotemporal control of posttranｓｃｒｉｐｔional gene regulation, smart nuclear/mitochondrial localization,simultaneous inhibition of multiple progression pathways of tumor cells for enhancing antitumor efficacysafety of cancer therapy.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

The present sperm sorting chip utilities the upstream swim characteristic of sperms in appropriate fluid velocity to achieve up to 80 high motility sperm yield for infertile males in just 40 minutes

Infertility is a serious globe issue, especially in the developed countries, over 20%infertile male has sperm problems, that include instance immotile, abnormal morphology and low sperm quantity. Therefore, how to isolate high quality sperm for clinical use is extremely required. Up to date, activity sperm sorting is usually using Swiming-up and Density gradient centrifugation approaches. Unfortunately, both methods are detrimental to the sperm viability and elicits production of reactive oxygen species. Separation sperm by microfluidics has been put emphasis on and studied; however, it faced some challenge such as low throughput and an unacceptable recover rate.

The microfluidic chips have been used to sort human motile sperms based on the phenomena of laminar flow. The sorted sperms would be fertilized to form the embryo by using in intracytoplasmic sperm injection (ICSI). The prototype of chips have been developed in the lab under National Tsing Hua University. Furthermore, the mass production has been conducted by Ritek to accomplish the disposable chips