癒合

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

NCREE has originally developed 5D digital space—on the basis of 3D city modelsconnections of different kinds of sensors around the world— is an online to offline virtual space with a combination of rising 5G technology advantages. Collectingreorganizing various 3D cartographic data with Building Information Modeling (BIM), satellite imagery, UAV 3D modeling, LiDar point cloud data, etc., can increase the diversity of the buildinglandscape. 5D+5G smart city platform would accelerate the 5D smart city to become the digital twin of a real city.

1. CNN model architecture optimization techniques: Propose an Agilev3-L architecture, with a performance index of mAP@50:95FPS:FP16 up to 171.79 2. GOP-mode acceleration scheme for real time inference: employ GOP-modeTRACKING algorithms to enhance the processing rate. 3. Propose a rapid data labeling system HiTag.

The self-healing ultra-high-performance concrete is a green construction material. It has the key characteristics of self-healing ability, high deformability, and ultra-high strength. The material composition contains a high proportion of by-products from industrial manufacturing. The particle packing density of the developed material is optimized to make this new multi-functional concrete material also have the ability of self-healing and deformability.

An innovative ointment solves an unmet clinical need to cure keloid wounds The composition of the ointment can precisely modulate the cell functionsgene expression of keloid fibroblasts, making them close to the performance of normal fibroblasts. Thereby, when applying the ointment to keloid woundsthe human body prone to the formation of keloid wounds, the wound is smoothed, healing close to normal skin.

Our results have demonstrated that our tissue gel can effectively promote angiogenesiswound healing in diabetic wounds. Our product prototype will be a powerful therapeutic product to treat diabetic foot ulcersgo further to rescue diabetic patients from amputation.

The bioactive corecorona synergism of sub-nanometer gold enables slowed inflammationincreased tissue regeneration in wound hypoxia. The developed dual-function wound dressing based on a gold nanocluster with a plane structurean adhesive layer presented two features: (1) the gold nanocluster can attenuate the inflammatory response by adjusting the strength of the active site (i.e., l

A novel “Platform Technology” in surgical hemostasis, based on biodegradable polyurethane particles with anti-inflammatory and nerve repair, not only accelerates wound healing but also provides solutions for hemostasis during surgery, and improve biocompatibility and adverse of commercially hemostats to achieve the best patient care. Our first product is aimed to provide a hemostatic agent, use on the bleeding surface and deep, with additional functions to surgeons, which allows customers to shorten the operation time, reduce stay in the hospital, and reduce the chance of secondary surgery.

This work synchronizes electrocardiograph to narrow-band imaging with high-power lens to observe the micro-circulation on the skin. The time difference among the arrivals of the cardiac pulse wave on different parts of the path is then used to calculate the pulse wave velocity of the arteries, providing very helpful diagnosis of diseases closely related to the peripheral circulation.

Epidermolysis bullosa (EB) is an inherited blistering skin diseaseis also one of the most "urgent, severe, difficultrare" diseases. Since there are at least 21 disease-causing genes involved in EB with markedly variable manifestations, it is particularly difficult for accurate diagnosis. In recent years, next generation sequencing (NGS) has been widely applied in the genetic diagnosis of rare hereditary disorders. The EB team in NCKU established the protocol of EB diagnosis by combining NGSvarious tools of pathologymolecular studies. Till now, we have completed the genetic diagnosis for more than 50 Taiwanese EB patients.

Our PEDD has been used to detect the HNE level in both tearwound fluids of 9 patients,the limitations of detection were about 0.76 μg/mL0.63 μg/mL respectively. Our device requires only 15 minutes, 3 μL of clinical sample for each test,offers superior sensitivity compared to other current HNE detection methods. The HNE concentrations in the patient samples have shown that the elevated HNE levels might suggest an abnormal healing of either acutechronic wounds, consistent with previous studies that showed excess protease levels in all non-healing wounds.

Chronic wound infection is a leading cause of mortality in injured patients worldwide. At present, available systemic antibiotic treatments have an insufficient tissue penetration ability and allow the development of antibiotic-resistant pathogens. The identification of therapeutic agents with wound healing and antimicrobial functions is necessary to heal the wound and cure infections. Our report shows that the antimicrobial peptide (AMP) Epinecidin-1 (Epi-1) efficiently heals MRSA-infected heat burn injuries and provides protection from infection in mouse and pig model. Our results demonstrate that the biomaterial Epi-1 heals wounds through increasing epithelial cell proliferation, vascularization, and the formation of collagen and controls MRSA infection-mediated sepsis in pigs.