生物科技

The proposed technologies apply deep learning methodsbig clinical data for lung cancer decision support. The system consists of: 1) CT radiogenomicspatho-genomics for automatic cancer detectionprediction of EGFR mutation 2) demographics to predict survival 3) genomics to predict cancer recurrencemetastasis,4) drug response inference for the best target therapy option. The modules are constructed on an AI-based Clinical Decision Support System (CDSS-SDM). The system is expected to provide physicianspatients with personalized medication recommendations.

We have developed an innovative acoustic vortex technology VorteSonic for treatment of VTE, with the first go-to-market product of a catheter-based acoustic vortex thrombolytic device. Acoustic vortex produces turbulent flow around the thrombus, resulting in effective thrombolysis by creating loose structure of thrombustherefore enhancing deep penetration of thrombolytic drugs into the thrombus. Advantages of the acoustic vortex technology is reduction of hemorrhagic riskimprovement of safetyprognosis. Feedback system can be integrated for intelligent therapy in the future.

These stimuli-switchable nanoparticles coated with the cleavable outer polymer coatingmultifunctional peptides may afford a new platform for anticancer drugmiR. These nanoparticles possess characteristics of environmental response, active targeting,gene/chemo combinatorial therapeutics, thus providing spatiotemporal control of posttranｓｃｒｉｐｔional gene regulation, smart nuclear/mitochondrial localization,simultaneous inhibition of multiple progression pathways of tumor cells for enhancing antitumor efficacysafety of cancer therapy.

This technique used algae-a natural raw ingredient as novel functional aquafeed additives, as replacement for fish meal in nutrition sources, a fish oil replacement in the feed, an algae strain contains unsaturated fatty acid can change level of serotoninblood cortisol in fish brain, decrease their cannibalism rate. This technique can reduce feed production costincrease harvesting rate.

The invention focuses on the early fry culture, including algae, live-food organism, water quality control, fine image detection,automated intelligent culture technology. By connecting environmental parameter sensing equipment, fine image observation equipment, automatic feedback/delivering equipment,central intelligent learning/processing platform, an intelligent production system of aquatic fry can be completed,the big data on production parameters can be collected, optimizing breeding strategiesefficiency,increasing the breeding profitability more than 10 times.

The innovative microbial wastewater treatment technology of our team can effectively reduce the COD, BOD, total nitrogen and total phosphorus in livestock wastewater to the emission standards in a short period of time, and the generated microorganisms can be developed for feed additives and organic fertilizers. In terms of industrial wastewater, this technology can also effectively clean petrochemical, ammonia nitrogen and heavy metal wastewater by degrading COD and ammonia nitrogen even adsorbing heavy metals, showing the excellent treatment performances.