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These stimuli-switchable nanoparticles coated with the cleavable outer polymer coatingmultifunctional peptides may afford a new platform for anticancer drugmiR. These nanoparticles possess characteristics of environmental response, active targeting,gene/chemo combinatorial therapeutics, thus providing spatiotemporal control of posttranｓｃｒｉｐｔional gene regulation, smart nuclear/mitochondrial localization,simultaneous inhibition of multiple progression pathways of tumor cells for enhancing antitumor efficacysafety of cancer therapy.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

Inorganic porous nanofibers with surfaceinterface defects are prepared through humidity-controlled electrospinninghigh-temperature annealing technology. Under the irradiation of light sources of different wavelengths (380~780 nm), the bound electrons stored in the valence band can be excited to the conduction band to form free electrons on the surface of the material, generating different intensities of microcurrents, light sensitivitymicrocurrent changes. Because the "inorganic nanofiber" technology has high uniquenesshigh product compatibility, it can be applied to a wide range of markets.

The AR-assisted endoscopic navigation system for brain surgery combines CT/MRI images, 3D cerebrovascular/nerve models,endoscopic images for surgical planningnavigation. AR glasses can display the 3D navigation inside the patient＇s skull, providing surgeons with intuitive 3D surgical navigation. In addition, the cerebrovascular/nerve model is also superimposed on the endoscopic image, allowing the surgeon to predict the upcoming surgical situation. The AR display endoscopic images can be simultaneously transmitted to the remote site for assistance through 5G communication.

During arthroscopic surgery, the anchor suture is easy to tangleunable to fix the soft tissue using conventional one lumen cannula. Thus we design a novel “Double lumen cannula” containing a flexible septum inside the cannula which can separatechange the cannula volume dynamically into two lumen. This would decrease the surgical timesoft tissue injury,improve the security of su

Optical coherence tomography using an optical probe with a diameter of 0.9 mm, combined with the 14-18 gauge needle, is used for clinical needle puncture. Using the real-time image obtained from the tip of the needle in the tissue, the needle position can be identified. Combined with artificial intelligence can achieve objective, accurate and automatic identification of the tissue, which has been successfully verified in anesthesia and laparoscopic surgery.