| Technical Name | COVID-19動物模式- 擬人化小鼠及免疫分析平台 | ||
|---|---|---|---|
| Project Operator | National Laboratory Animal Center, National Applied Research Laboratories | ||
| Project Host | 秦咸靜 | ||
| Summary | Two COVID-19 animal models, including humanized Ace2 micehuman peripheral blood lymphocyte transplanted mice, are used to mimic COVID-19 infection, immune responsecytokine release syndrome in human. The immune analytical platform can further outline the immune cell, cytokinebiomarker response pattern after viral infection. The COVID-19 humanized animal modelthe immune analytical platform will support COVID-19 related researchfacilitate new drugnew therapy validation. |
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| Scientific Breakthrough | The humanized ACE2 model employed a unique human/mouse chimeric receptor design to mimic viral entry ability of human ACE2 receptorremain the intracellular signal transduction ability of mouse Ace2 receptor. The hPBMC-HIS ASID mice is a novel CRS model that can reveal the immune profile , such as IL-6, IFN-TNF-, in cytokine release syndrome after severe infection. The immune analytical platform can further outline the immune cell, cytokinebiomarker response pattern after viral infection. |
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| Industrial Applicability | The humanized modelsthe analytical platform can be used for the evaluation of preclinical antiviral therapyvaccine effectiveness. |
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| Matching Needs | 天使投資人、策略合作夥伴 |
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| Keyword | pathological analysis blood biochemistry cytokine immunohistochemistry viral particle immune cells T cell macrophage neutrophil flow cytometry | ||
- 1007932@narlabs.org.tw
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