The invention integrates a variety of technologies including stem cell proliferation, directed inductioncryopreservation in vitro. This integrated system was developed under chemical defined condition,can expand various type of stem cells over one hundred foldcan furtherly induce to specific mature cells up to ten millions. In addition, the amount of cryoprotectant can be significantly reduced to 2 in the cryopreservation system with excellent cell survival rate. This integrated system can provide a promisingvarious stem cell sources for cell therapyimmunotherapy.

This technology integrates the proliferation, directed inductioncryopreservation systems for stem cellsmature cells. Under the chemical defined condition, this integrated system can expand stem cells over one hundred folddirectly induce expanded stem cells into a variety of adult cells up to ten million. Compared with commercial products, this technology has better cell proliferation rate,can also achieve excellent survival rate under 2 DMSO conditions, which is superior to products on the market. This integrated system is suitable for cellimmunotherapy.

This integrated system can be applied in related industries of cellimmunotherapy, vaccine production, clinical trialcell culture. This integrated system can massively expanddirectly induce various types of adult stem cells (such as hematopoietic stem cells, mesenchymal stromal cells, endothelial progenitor cellsintestinal stem cells), embryonic stem cells, induced pluripotent stem cellsvarious bloodimmune cells under serum-free condition. In addition, this integrated system also can be used for cryopreservation of above mentioned cellsplant cells.

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