| Technical Name | Small- and Wide-angle X-ray Scattering on Biological Structures | ||
|---|---|---|---|
| Project Operator | National Synchrotron Radiation Research Center | ||
| Project Host | 鄭有舜研究員 | ||
| Summary | (1) High flux mode for integrated measurements of SAXS/WAXS/UV-Vis-absorption/Refractive-index/Multi-angle-light-scattering (MALS) with an online high-performance liquid chromatography (HPLC) instrument, suitable for exploring biomacromolecular solution structures of a wide length scale and structural kinetics down to microsecond time scale. (2) Ultra SAXS (USAXS) mode for resolving hierarchical structures of bio-machinery assembly up to a few um length scale. (3) Anomalous SAXS mode for metal or mineral distributions (including calcium) in bio organelle or drug carriers. (4) Microbeam SAXS/WAXS mode for structural mapping of the textures or specific infected cells in natural/synthetic bio-tissues, organelles, or biomaterials. |
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| Scientific Breakthrough | This TPS BioSAXS beamline outperforms many worldwide SAXS beamline in biostructural research. There are three major breakthroughs of the new beamline, including (1) high flux mode for integrated measurements of SAXS/WAXS/UV-Vis-absorption/Refractive-index/Multi-angle-light-scattering (MALS) with an online high-performance liquid chromatography (HPLC) instrument, suitable for exploring biomacromolecular solution structures of a wide length scale and structural kinetics down to microsecond time scale. (2) Ultra SAXS mode for resolving hierarchical structures of bio-machinery assembly up to a few um length scale. (3) Microbeam SAXS/WAXS (mSAXS) mode for structural mapping of the textures or specific infected cells in natural/synthetic bio-tissues, organelles, or biomaterials. |
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| Industrial Applicability | Ø Fast structural screening process for biomolecules with molecular mass from 1 kD to 10000 kD. Ø Allergen and allergic-reaction-induced structural changes. Ø Interaction between metallic nanoparticles and lipid molecules and its connection to inflammation inhibition. Ø Protein misfolding and aggregation in Alzheimer‘s and other RAN/DNA related diseases. Ø Structural and compositional analysis of combined antiretroviral (ARV) drugs used in ARV therapy. Ø Other cancer-related studies like solution-based structural analysis of phosphatases and glycoprotein. Ø Diary products in solution, gel, or solid forms. |
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| Matching Needs | - |
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| Keyword | Biological small- and wide-angle X-ray scattering Fast structural screening process Allergic-reaction-induced structural changes Metallic nanoparticles and lipid molecules Protein misfolding and aggregation RAN/DNA related complexes Diary products in solution, gel, or solid forms Intrinsically disordered proteins | ||
- usjeng@nsrrc.org.tw
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