| Technical Name | Influenza virus-like particle vaccine production using baculovirus expression system | ||
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| Project Operator | National Health Research Institutes | ||
| Project Host | 胡勇誌 | ||
| Summary | Vaccination is the most effective way to prevent influenza viruses infection. The egg-based production method has many drawbacks, we established baculovirus-based VLPs expression platform for H7N9 VLPs production, purify the VLPs satisfied with FDA regulation, and improved its immunogenicity to the same level compared with H7N9 whole virus vaccine. |
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| Scientific Breakthrough | Vaccination is the most effective way to prevent influenza viruses infection. The egg-based production method has many drawbacks, we established baculovirus-based VLPs expression platform for H7N9 VLPs production, purify the VLPs satisfied with FDA regulation, and improved its immunogenicity to the same level compared with H7N9 whole virus vaccine. |
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| Industrial Applicability | In order to providing safer quality of influenza vaccine and improving its immune effect, the virus-like particle influenza vaccine platform can significantly reduce the cost (no need for high-risk biosafety level II or III production plants) and also be used for seasonal influenza vaccine production as well as other human infectious diseases. |
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| Keyword | Influenza virus Influenza vaccine virus-like particle (VLP) influenza vaccine Influeza vaccine production platform immunogenicity suspended MDCK cells Influenza H7N9 virus baculovirus expression system insect cells VLP purification method | ||
- alanhu@nhri.edu.tw
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