Technical Name | Nebulum3D Bioimaging System | ||
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Project Operator | National Tsing-Hua University | ||
Project Host | 江安世 | ||
Summary | Nebulum 3D Bioimaging combines Tissue Clearing, Light-Sheet Microscopy, and Tissue Expansion, to provide a streamlined bio-imaging service that bypasses the conventional sectioning technique and provides whole-tissue, multiplex, single-cell resolution imaging data. |
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Scientific Breakthrough | We are the first in the world to observe a memory protein's formation on a single neuron with specific 3D coordinates at single-protein resolution using Nebulum3D in a drosophila brain. We also found that other types of memory protein will accumulate on the same neuron during new memory formation. |
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Industrial Applicability | Nebulum3D is the next generation tool for tissue morphology and pathology analysis. This technology can be applied to brain structural and related drug development projects, high-speed cancer drug screening and analysis, and pathological detection and diagnosis. |
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Keyword | Multiscale Light-Sheet Imaging Super-Resolution Imaging Whole-Tissue Imaging Tissue Clearing Tissue Expansion 3D Drug Screening 3D Pathology Bioimaging Alzheimer's Memory |