Nano-sized silicon reacts rapidly with most water solutions to form pure hydrogen. However, high costlow availability are major issue. Our group has developed novel nano-sized silicon mass-production process, greatly improves its feasibilitycost for hydrogen generation. The in-time hydrogen generation by nano-size silicon, fuel-cell systemlithium ion battery system are all well integrated into one portable power system, which can satisfy general personnel electricity demand for some special conditions, such as battle field, emergency caseremote regions.

The interpretation of next generation sequencing is a big challenge. In order to improve the molecular diagnosis of the patient, we developed the AI_Variant prioritizer, a machine learning based variant prioterization system that can help to prioritize candidate variants for human disease. This module highlighted the possible disease causing variants to help clinician to increase the disease diagnostic yield and decrease the load of manpower.

In the current of study, cell subsets, cell proportionsthe immune function of tumors-infiltrating leukocytes were used to indicate the features of tumor immune microenvironment in non-small cell lung cancers (NSCLCs) with different type of EGFR genetic alteration.

ALTOMS (Altomated Laser TrackingOptogenetic Manipulation System) is a real-time computer vision object recognitionlaser tracker. It uses a missile-like image recognitiontracking technology,uses several lasers to accurately hit the tracked object. The laser itself does not have the function of controlling nerves, but when we express light-sensitive proteins on specific nerve cells, we can stimulateinhibit nerves through lasers of specific wavelengths, which will affect the behavioral outcome.

This invention presents a "next-generation augmented reality navigation system” using the generative adversarial network-long short term memory network (GAN-LSTM) framework with integrated GPS module to implement a novel AR navigation system. Unlike the presented AR navigation system, the virtual guided path is "autonomously generated" in captured image rather than superimpose on the image by using the pre-rendered 3D content, which not only provide a more authenticcorrect AR effect to user but also earlycorrectly guide the driver when driving in complex road traffic environment.

"1. Automatically generate Verilog code tools based on the hardware architecture of convolutional neural networks: 4 different hardware architectures (output stationary, weight stationary, Tree architecture, NVDLA) can be generated for the currently more commonly used DNN networks. 2. Visual performance index analysis tool: According to the selected DNN model,the choice of hardware architecture specifications, analyze the performance index."

Induced pluripotent stem cells are a promising new technology in translation medicine,AI technology is an automaticpowerful platform that can help identify cell images with unique characteristics, predictprovide information about cell types, differentiation stages, cell quality,normal Or disease-specific feature information. The combination of this induced pluripotent stem cell differentiation platformAI-based artificial intelligence image analysis technology will have great benefits for future cell product applications.

The goal of this project is to study "low-temperature magnesium hydrogen storage materials and energy storage applications". Mg hydrogen storage materials with a hydrogen storage capacity of 5.0 wt% is developed,and their dehydrogenation rate at 250℃ will be significantly enhanced using a forcible pump. The Mg hydrogen storage powders are inserted into a tank for cyclic hydrogenation-dehydrogenation tests. The H2 gas desorbed from the tank is supplied to a high-temperature proton exchange membrane fuel cell (HT-PEMFC,160℃) for power generation.

These stimuli-switchable nanoparticles coated with the cleavable outer polymer coatingmultifunctional peptides may afford a new platform for anticancer drugmiR. These nanoparticles possess characteristics of environmental response, active targeting,gene/chemo combinatorial therapeutics, thus providing spatiotemporal control of posttranｓｃｒｉｐｔional gene regulation, smart nuclear/mitochondrial localization,simultaneous inhibition of multiple progression pathways of tumor cells for enhancing antitumor efficacysafety of cancer therapy.

Gene delivery technology is widely used in cell therapy, nucleic acid-based vaccines, protein production, gene therapy, etc. We have developed a non-viral gene delivery technology-MPGene, which has excellent gene delivery efficiency (50-80) for human mesenchymal stem cells,also has the characteristics of low production costhigh safety. In the future, MPGene has the potential to be used in important biomedical fields such as gene delivery reagents, major trauma cell therapy, malignant tumor treatmentcartilage cell therapy.

We developedoptimized a FRET-based genetically-encoded biosensor Met-lead with high sensitivity 10nM (0.2μg/dL, 2ppb) to fit the related regulations: the safety value of blood lead level for children 3μg/dLWHO-permitted level for tap water 10ppb. We further built a portable smart-phone device to measure Pb on-site. The practical applications of portable Met-lead can fulfill the needs from blood/urine Pb detection to drinking water/environmental irrigation water Pb monitoring, it will also help to build up a warning system to prevent further contamination from heavy metal Pb.

Supramolecular nanoparticles is a convenient, flexible,modular synthetic non-viral gene delivery vehicle for drug/gene delivery. The self-assembly of SMNPs is enabled upon mixing three different molecular building blocks, namely CD-PEI, Ad-PAMAM,Ad-PEG via Ad/CD motif-based molecular recognition. This allows modular control over the sizes, surface chemistry,payloads of SMNP vectors, thus holding promise for diverse therapeutic applications, especially for developing nanoparticle-based gene delivery platforms.

In this research, we developed two platforms for analyzing mitochondrial stress. One is to use CRISPR/Cas9 editing to mark a variety of mitochondrial proteins in C. elegansmammalian cells for in vivo assessing mitochondrial functions. Another one is to establish a light-induced DNA damage specifically in mitochondria. In the meanwhile, we also developed a method to

This research presents a genetic variant discovery SoC for analyzing Next-generation sequencing data which is embedded with the processorconnected with some peripherals. With hardware-optimized algorithm sBWT, we greatly speed up the process of short reads mapping by k-ordered FM-indexsuffix grouping. After short reads mapping, we utilized de bruijn graph for sequence assembly to rebuild haplotypes,built haplotypes are compared to the reference genome to detect genome variations. The detected variations are written to files for further clinical diagnosisresearch analysis.

Our team has developed a layer-by-layer hydrophilic membrane (LHM) as the “bendable water-enabled portable power banks”. It is bendable, cost-effective, lightweight, environmental-friendly,high-efficient. Moreover, it could achieve high-voltage (~0.8 V), high-current (~80 μA)long-lasting (4 hr) power output by dropping a few drops of DI water (or electrolyte solutions), which can be described as a "black technology" towards green clean energy.

Current 5G communication devices have a huge demand in high resolutiondensity of metal conducting wires in electronics ( 40 μm line width/line spacing), which cannot be achieved by conventional screen printing (100 μm). Our group cooperated with Ample Technology to develop a new-generation silver conductive paste which enables photolithographyachieves outstanding line resolution (5 μm width/13 μm spacing). The paste is simple to useperforms comparable of those of major European, AmericanJapanese manufacturers.

We have successfully developed a multiphoton-induced hyperspectral microscopy based on a 1064 nm femtosecond excitation source. Nonlinear excitation by the laser localized to the focal point allows efficient non-descanned detection (NDD) while achieving optically sectioned imaging. The use of 1064 nm laser excitation increases the imaging depth while minimizing sample damage. The system combines the advantages of NDD for 3D imagingrich spectral information through confocal hyperspectral imaging, leading to potential applications in the emerging material R&Dbiomedical research.

Harmoscope is a virtual biopsy technology for dermatology. The superior performances of in vivo Harmoscope has been clinically validated by NTU hospital for 14 years, with the deepest penetration, super-resolution,the highest contrast all at the same time. Without imaging processinglabeling, Harmoscope raw images provide the same level of resolutioninformation as the time-consuming gold standard H&E histopathology, allowing dermatologists and pathologists to grade and classify various skin lesions for immediate therapeutic decision without physical biopsy. This award-winning technology will release the saturated loading of skin biopsy examination, greatly improve the quality of point of care, while providing a trauma-free real-time alternative for skin lesion patients.

Our previous studies suggested that increase Cisd2 levels may attenuate the pathogenesis of NAFLD/NASH. Accordingly, potent Cisd2 activators with the capacity to enhance Cisd2 levels were identified through the screening of skeletally diverse collections and structural optimization. So far BPRCD0001S0 is the most potent Cisd2 activator obtained, which has been studied extensively. Data obtained revealed that BPRCD0001S0 has no detectable toxicity in vivo, can activate Cisd2 in liver and ameliorate obese-related and fructose-induced NAFLD/NASH.

Epidermolysis bullosa (EB) is an inherited blistering skin diseaseis also one of the most "urgent, severe, difficultrare" diseases. Since there are at least 21 disease-causing genes involved in EB with markedly variable manifestations, it is particularly difficult for accurate diagnosis. In recent years, next generation sequencing (NGS) has been widely applied in the genetic diagnosis of rare hereditary disorders. The EB team in NCKU established the protocol of EB diagnosis by combining NGSvarious tools of pathologymolecular studies. Till now, we have completed the genetic diagnosis for more than 50 Taiwanese EB patients.

A Metal-Supported Solid Oxide Fuel Cell (MS-SOFC) unit cell with high electricity power output, stability, thermal-shock, mechanical-shock resistanceanti-redox abilities was successfully produced by a continuous fabrication process. This product can be installed not only in stationary SOFC power system but also in transportation set-up. The core technology of the fabrication process is Atmospheric Plasma Spraying (APS) technique which was employed to produce desired functional oxide lays onto permeable Nickel-base super alloy substrate.

Our technologies are able to analyze customer behaviorsprovide personalized automatic services. We take two directions: (1) Establish a customer behavior predictionrecommendation system by analyzing consumption records, exploring behavior features,strengthening the link between marketing strategiesbehavior analysis (2) Collaborative EDM subjects generation by analyzing the relationship between customers’ click recordsconsumption for understanding the relationship between customer intentionsfinancial products,for generating personalized marketing strategies.

The proposed technology erects the solar panel in installation. The reflector can be adjusted to modulate the percentage of sunlight for photovoltaic generationillumination in corresponding to the change of weatherseason.

R3CE (Rapid, Reproducible, Rare Cell 3D Expansion) is a clinically validated platform capable of generating single cell-derived organoids within one to four weeks. It outperforms currently 3D culture technologies in terms of yields, time to form organoids,easiness of operation. It also demonstrates similar yieldscost structure to 2D culture protocols. R3CE is ready for drug testing for all clinical samplesprovides sufficient quantity of genomic samples derived from cancer patients. It would help conduct clinical cancer treatment in the translational study.

Active phased arrays of antennas suffer from fabrication discrepancy at mmW frequencies for 5G/B5G. To accelerate the piece-by-piece calibration procedure, a bottleneck to cause high fabrication cost, a highly efficient electronic-scan based technique is developed. By avoiding the time-consuming mechanical probing, the developed technique is particularly applicable to production line operation to

mmW 5G/B5G/6GLEO satellites use large active antenna arrays of more than 1000 elements. A number reduction aided by low cost intelligent panels is developed to reduce at least 60 cost. AiPAiM are used to compact the array with reconfigurability at low power losses. The gains are compensated by phase-reconfigurable AiP/AiM to feed smart multi-beam panels of large apertures. It may steer directional beams by operating the active RF modules tightly fed by AiP/AiM based arrays. Tile architecture can be implemented using multiple AiPs/AiMs for flexible array configurations.

SS-MRAM is a superlattice based magnetoresistive RAM, in which the barrier is made of superlattice to replace crystal MgO (001). The superlattice is a high spin polarization artificial metamaterial, which is composed of stable insulatormetal materials. Compared with the current STT-MRAM, SS-MRAM has the advantages of low readingwriting power consumption, fast readingwriting speed, s

This technique uses multimodal nonlinear optical microscopy with the image contrast of second harmonic generation (SHG)coherent anti-Stokes Raman scattering (CARS). By analyzing the nonlinear signals on images, it can be used to characterizequantify the structural variation in the collagen scaffolds processed with different crosslinking methods. The correlation between signalsmechanical properties can then be derived. Additionally, comparative analysis of these two signals can be used to monitor the structural (triple-helix) change of collagen molecules during the crosslinking processes.