A method of enhancing a mammalian immune response to a virus is disclosed. The method comprises administering a composition comprising an effective amount of epinecidin (Epi)-1the virus to a mammal, wherein the virus has envelope proteinis infectious to the mammal. In this technique, Epi-1Japanese encephalitis virus (JEV) were mixedinjected into mice. The mice were infected with JEV 14 days later,all mice survived. This technology has also been verified in the preparation of vaccines for foot-and-mouth disease virusnervous necrosis virus.

Chronic wound infection is a leading cause of mortality in injured patients worldwide. At present, available systemic antibiotic treatments have an insufficient tissue penetration ability and allow the development of antibiotic-resistant pathogens. The identification of therapeutic agents with wound healing and antimicrobial functions is necessary to heal the wound and cure infections. Our report shows that the antimicrobial peptide (AMP) Epinecidin-1 (Epi-1) efficiently heals MRSA-infected heat burn injuries and provides protection from infection in mouse and pig model. Our results demonstrate that the biomaterial Epi-1 heals wounds through increasing epithelial cell proliferation, vascularization, and the formation of collagen and controls MRSA infection-mediated sepsis in pigs.

We developed Polypyrrole (PPy) based NIR-photothermal related platform technologies. This photothermal driving hyperthermia carrier systems are biocompatible are able to possess versatile functions in anticancer, antibacterial, thrombolysis, wound-healingsuppression of inflammation related bioengineering potential applications. These innovative works shed light on the efficacy of combining photothermal-performance with translational manner in biomedical, clinicalindustrial designs.

High entropy materials were proposed and developed by Professor Jien-Wei Yeh in 1995. He named, defined, and elucidated “High-Entropy Alloys,” as well as established High-Entropy Materials Center to develop critical materials for smart machine, green technology, biomedical technology, and national defense. Alloys with high strength, corrosion resistance, and anti-bacterial capability are also developed for manufacturing knives, door handles, handrails, etc. to prevent infection during the post-epidemic era.