The innovative technology is based on the unique biomimetic material, including immunomagnetic nanoparticlesa portable IoT detection device, promoting the detection speed, accuracy,precision of the target molecule. Featuring with the excellent ability of minimizing the non-specific binding, this technology decreases false negative/false positive successfully. The device combines IoTAI module for statisticscalculation on the cloud for building up a magneto-electrochemical IoT sensing system for the integrated isolationprofiling of extracellular vesicles from plasma.