The high-frequency jet ventilator uses the solenoid valve and feedback techniques to control the operational parameters of the ventilator. The proposed dual-mode control mechanism allows dynamic adjustment of the tidal volume, pressure, and duration of ventilation simultaneously. The system has been verified in animal experiments and demonstrated a significant improvement in the gas exchange efficiency. Besides, the bioelectrical impedance measurement can provide real-time and accurate regional information of the lungs, which helps to monitor the patient’s condition during respiratory treatment. This work also adopts wireless communication and remote-control technology to reduce the risk of infection of medical professionals.

Ted-ICU AI Platform: (1)Provide a single view of patients＇ EMRsvital signs (2)Support remote ICU monitoring (3)Online labeling tool & Expandable AI algorithms repository (4)Disease-specific prediction models (5)Standardized EMR templates

We developed a wearable ultrasound monitoring device to monitor the collapse of tongue roots of sleep respiratory patients throughout the night,completed clinical trials in the sleep center. The experimental results show that this device can effectively monitor OSA. The tongue structure changes at the timeintegrates ultrasound information into the commercial PSG system. It is expected

In this project, we have reorganized several highly immunogenic sitesstructurally essential regions to maintain it in a pre-fusion stateuse it as main antigen in our RSV vaccine candidate (RSV-F005). To induce a mucosal immune response, intranasal administration route was chosen. New mucosal adjuvant (H-muad) has been tested in threee animal models.

Effectively inducing cytotoxic T cell expansion has been a critical challenge in vaccine development. To address this challenge, an entirely biodegradable polymeric nanoshell was invented to couple antigensadjuvants for safepotent immune potentiation. The invention has been adopted for precision anticancer vaccine, broadly reactive influenza vaccine,an effective vaccine MERS-CoV.

The technology provides a new experience for remote respiratory rehabilitation care,let patients realize self-health management at home. The system has three characteristics: First, daily home pulmonary function tests to achieve early warning of disease. Second, the design of automatic feedback aperture valve provides the best positive expiratory pressure (PEP)for pulmonary rehabilitation,APP helps user to do breathing exercise. Third, electronic monitoring of inhaled medications with a two-way flow sensor module,APP helps user to guide the inhalation process.

We use features such as asymmetric expression and crooked eyes to assess the risk of facial stroke. Observing the micro vibration of the head caused by the contraction of the heart, and develop a zero-contact facial heart rate and respiration rate detection technology in conjunction with the camera. The technology can accurately measure heart rate and respiration rate in real time, thereby reducing the risk of infection. This technology has obtained two ROC patents (M590433, I689285), two US patents (HEART RATE DETECTION METHOD AND DEVICE THEREOF,MOUTH AND NOSE OCCLUDED DETECTING METHOD AND SYSTEM THEREOF). The possibility of detecting strokes through AI machine learning methods is not only accurate, but also find out signs of stroke early to grasp the best time to seek medical treatment.

The proposed indoor radar sensing system includes two enabling technology, activity recognitionrespiration rate estimation. In the former, the proposed framework consists of four major components: denosing, enhanced voxelization, data augmentation,dual-view machine-learning to lead to accurateefficient human-activity recognition. In the latter, the proposed system leverages the variation of the phase information of a specific frequency bin of the range profiles,proposes a dynamic adaptive respiration waveform filtering algorithm to improve accuracy.

PRRSV recombinant antigen A1 inhibits the expression of CD163 on the cell surface by inducing the polarization of M1 macrophage subset, which can further effectively reduce virus invasionreduce infection. A1 can regulate the endogenous genes of alveolar macrophages to activate Th1-type immune responseenhance cellular immunity. Therefore, this technical invention will be beneficial to screen the new generation of PSSRV candidate structural vaccines.

In this technology, a series of potent MOR/NOP agonists has been developed, which demonstrated potent antinociception in tail flick and cancer pain mouse models with fewer side-effects in respiratory suppression, heart rate decreasing, and constipation models than morphine.

This technology is used micro-electro-mechanical systems combined nanomaterials and micro-heater systems, because the interdisciplinary integrated manufacturing technologies are used to make miniaturized sensor elements, which are equipped with bluetooth functions of algorithms and detection devices to monitor the ketones gas concentration during patient breathing applied in healthy care.